INDOLACTAM V

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H23N3O2
Molecular Weight	301.3834
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@@H]1N(C)C2=CC=CC3=C2C(C[C@@H](CO)NC1=O)=CN3

InChI

InChIKey=LUZOFMGZMUZSSK-LRDDRELGSA-N

InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3109758 | https://www.ncbi.nlm.nih.gov/pubmed/27074538 | https://www.ncbi.nlm.nih.gov/pubmed/21048796

Indolactam V is a tumor promoter and a nanomolar agonist of protein kinase C. The compound was shown to induce differentiation of stem cells into pancreatic progenitors through activation of PKC signaling.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cancer 592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21542090	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Teleocidins and benzolactams inhibit cell killing by human immunodeficiency virus type 1 (HIV-1).	1994 Aug	7820129

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

LNCaP and U937 cells were treated for 72 h with indolactam V at concentrations 1, 10, 30, 100, 300, 1000, 3000, 10000 nM (LNCaP cells) and 1, 10, 100, 1000, 10000 nM (U937 cells). IC50 values were 64.17 and 337 nM, respectively.

Name

Type

Language

INDOLACTAM V

Common Name

English

INDOLACTAM V, (-)

Common Name

English

3H-PYRROLO(4,3,2-GH)-1,4-BENZODIAZONIN-3-ONE, 1,2,4,5,6,8-HEXAHYDRO-5-(HYDROXYMETHYL)-1-METHYL-2-(1-METHYLETHYL)-, (2S,5S)-

Systematic Name

English

ILV, (-)

Common Name

English

Code System Code Type Description

MESH

C043969