Ortho-iodohippurate (also known IODOHIPPURATE) as is used for the determination of effective renal plasma flow. It is a halogen derivative of a compound normally found in human urine, and as the end product of a process of detoxification is synthesized in the body. This compound is nontoxic, when administrated intravenous. In patients with normally functioning kidneys, 85% of the ortho-iodohippurate may be found in the urine 30 minutes after intravenous injection. It is eliminated mainly by tubular secretion.