Isobutyric acid

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H8O2
Molecular Weight	88.1051
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C(O)=O

InChI

InChIKey=KQNPFQTWMSNSAP-UHFFFAOYSA-N

InChI=1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)

HIDE SMILES / InChI

Molecular Formula	C4H8O2
Molecular Weight	88.1051
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Role of short-chain fatty acids in colonic HCO(3) secretion.	2005-06	15677553
Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta 1, epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner.	2005-05-10	15645414
Formation pathways of ethyl esters of branched short-chain fatty acids during wine aging.	2005-05-04	15853394
Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis.	2005-03-18	15647252
Response of HT115, a highly invasive human colorectal adenocarcinoma cell line, to sodium butyrate treatment and glucose deprivation.	2005-03	15703838
Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus.	2005-02-01	15667998
Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase.	2005-02	15699210
Ruminal fermentation and amino acid flow in Holstein steers fed whole cottonseed with elevated concentrations of free fatty acids in the oil.	2005-02	15653536
Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells.	2005-02	15645120
Effect of carbohydrate source on ammonia utilization in lactating dairy cows.	2005-02	15644514
Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique.	2005-01-20	15620868
Gene expression associated with the decrease in malignant phenotype of human liver cancer cells following stimulation with a histone deacetylase inhibitor.	2005-01	15586245
Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology.	2005	15660381
Novel stable fluorophore, 6-methoxy-4-quinolone, with strong fluorescence in wide pH range of aqueous media, and its application as a fluorescent labeling reagent.	2004-12-03	15628146
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.	2004-12	15634758
Isolation of Lactobacillus sakei strain KJ-2008 and its removal of characteristic malodorous gases under anaerobic culture conditions.	2004-12	15618611
Effect of increasing ruminal butyrate absorption on splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers.	2004-12	15537776
Effect of anaerobic fungi on in vitro feed digestion by mixed rumen microflora of buffalo.	2004-11-13	15535463
Separation and determination of lanthanides, thorium and uranium using a dual gradient in reversed-phase liquid chromatography.	2004-10-15	15527129
Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive.	2004-10-13	15469255
Methanogenic pathway and archaeal community structure in the sediment of eutrophic Lake Dagow: effect of temperature.	2004-10	15692859
Performance and caecal adaptation of turkeys to diets without or with antibiotic and with different levels of mannan-oligosaccharide.	2004-10	15595620
Effects of substrate, passage rate, and pH in continuous culture on flows of conjugated linoleic acid and trans C18:1.	2004-10	15377625
Unusual ADP-forming acetyl-coenzyme A synthetases from the mesophilic halophilic euryarchaeon Haloarcula marismortui and from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.	2004-10	15340786
Thermodynamic analysis of product formation in mesophilic acidogenesis of lactose.	2004-09-30	15334408
Three distinct mechanisms of HCO3- secretion in rat distal colon.	2004-09	15308466
Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers.	2004-07	15309950
Effects of Sapindus saponaria fruits on ruminal fermentation and duodenal nitrogen flow of sheep fed a tropical grass diet with and without legume.	2004-05	15144079
In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide.	2004-04	14718604
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.	2004-02-26	14971910
Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases.	2004-02	14966533
Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling.	2004-02	14742672
Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat.	2004-02	14667475
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	2004-01-27	14722361
Binding energies of water to sodiated valine and structural isomers in the gas phase: the effect of proton affinity on zwitterion stability.	2003-11-05	14583055
Ruminal fermentation and bacterial protein synthesis of whole cottonseed coated with combinations of gelatinized corn starch and urea.	2003-11	14672196
[Antioxidant properties of rhenium cluster complexes with butyric acid derivatives in blood plasma and erythrocytes].	2003-10-25	14574740
On the water promoted reaction of titanium isopropoxide with carbon dioxide.	2003-10-21	14594278
Kinetics of thermophilic, anaerobic oxidation of straight and branched chain butyrate and valerate.	2003-10-20	12966576
Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge.	2003-09	13130036
Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) on microbial growth in continuous culture.	2003-08	12939087
Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.	2003-07-11	12724314
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.	2003-07-11	12711604
Altering soluble and potentially rumen degradable protein for prepubertal Holstein heifers.	2003-06	12836949
Crystallization of butyrate kinase 2 from Thermotoga maritima mediated by vapor diffusion of acetic acid.	2003-06	12777787
Actinidia arguta: volatile compounds in fruit and flowers.	2003-06	12737978
Aeromonas hydrophila subsp. ranae subsp. nov., isolated from septicaemic farmed frogs in Thailand.	2003-05	12807217
Degradation of isobutyraldehyde and its intermediates in a compost biofilter.	2003	15296161
High-rate anaerobic hydrolysis and acidogenesis of sewage sludge in a modified upflow reactor.	2003	14531424
Ecdysteroid 7,9(11)-dien-6-ones as potential photoaffinity labels for ecdysteroid binding proteins.	2002	15455045

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:48 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:48 GMT 2025`
Record UNII	8LL210O1U0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Isobutyric acid

Official Name

English

2-METHYLPROPANOIC ACID

Preferred Name

English

DIMETHYLACETIC ACID

Systematic Name

English

ISOPROPYLFORMIC ACID

Systematic Name

English

ISOPROPYLFORMIC-ACID

Systematic Name

English

ISOBUTANOIC ACID

Systematic Name

English

2-METHYLPROPANOIC ACID [HSDB]

Common Name

English

ISOBUTYRIC ACID [FCC]

Common Name

English

FEMA NO. 2222

Code

English

NSC-62780

Code

English

ISO-BUTYRIC ACID

Common Name

English

ISOBUTYRIC ACID [FHFI]

Common Name

English

.ALPHA.-METHYLPROPANOIC ACID

Systematic Name

English

ISOBUTYRIC ACID [MI]

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

ISOBUTYRIC ACID