IODOHIPPURIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8INO3
Molecular Weight	305.0692
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CNC(=O)C1=CC=CC=C1I

InChI

InChIKey=CORFWQGVBFFZHF-UHFFFAOYSA-N

InChI=1S/C9H8INO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13)

HIDE SMILES / InChI

Molecular Formula	C9H8INO3
Molecular Weight	305.0692
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1111/j.1464-410X.1935.tb11294.x Retrived from http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.1935.tb11294.x/abstract

Ortho-iodohippurate (also known IODOHIPPURATE) as is used for the determination of effective renal plasma flow. It is a halogen derivative of a compound normally found in human urine, and as the end product of a process of detoxification is synthesized in the body. This compound is nontoxic, when administrated intravenous. In patients with normally functioning kidneys, 85% of the ortho-iodohippurate may be found in the urine 30 minutes after intravenous injection. It is eliminated mainly by tubular secretion.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal plasma flow 3 Sources: DOI: 10.1111/j.1464-410X.1935.tb11294.x	Diagnostic		Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Simplified methods for estimation of 99mTc-pentetate and 131I-orthoiodohippurate plasma clearance in dogs and cats.	2001 May-Jun	11380028
Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.	2004 Jan	14734677
Idiopathic neurohypophysial diabetes insipidus: reversibility of structural and functional renal abnormalities after treatment.	2004 Nov-Dec	16033721
Effects of contrast media on renal function in patients with cirrhosis: a prospective study.	2004 Sep	15349903
Validation of neutron activation as a novel method to determine glomerular filtration rate.	2007	17940340
Synthesis and mass spectroscopy kinetics of a novel ternary copper(II) complex with cytotoxic activity against cancer cells.	2007 Apr	17292964
Availability and use of essential medicines in China: manufacturing, supply, and prescribing in Shandong and Gansu provinces.	2010 Jul 17	20637116
Glomerular filtration rate measured by (51)Cr-EDTA clearance: Evaluation of captopril-induced changes in hypertensive patients with and without renal artery stenosis.	2010 Jun	20613937

Patents

Sample Use Guides

In Vivo Use Guide

in rats: 2 g/kg bw

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:10:54 GMT 2023` Edited by `admin` on `Fri Dec 15 16:10:54 GMT 2023`
Record UNII	3Y68K91A3M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOHIPPURIC ACID

Systematic Name

English

IODOHIPPURATE

Systematic Name

English

O-IODOHIPPURIC ACID [USP-RS]

Common Name

English

O-IODOHIPPURIC ACID

Systematic Name

English

IODOHIPPURATE [VANDF]

Common Name

English

Iodohippuric acid [WHO-DD]

Common Name

English

GLYCINE, N-(2-IODOBENZOYL)-

Systematic Name

English

Code System Code Type Description

RS_ITEM_NUM

1344305