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Restrict the search for
clobetasol propionate
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2006)
Source URL:
First approved in 1974
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
BioSebMousse by VetBiotek, Inc.
(2016)
Source URL:
First approved in 1968
Source:
NDA204017
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Possibly Marketed Outside US
Source:
NDA012911
(1961)
Source URL:
First approved in 1961
Source:
NDA012911
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Estrone, the metabolite of estradiol, is used alone or in combination with other natural estrogens, in the form of ester (acetate, propionate~ or as hydrosoluble conjugate (sodium or piperazine sulphate) in the substitutive hormonal therapy (hypoestrogenic) and in the prevention of the bone loss in the cases of post-menopausal osteoporosis or in oophorectomized women.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Estriol tripropionate (brand name Estriel), or estriol tripropanoate, is semisynthetic, steroidal estrogen. Estriol is a safe estrogen hormone that has been used for decades in Europe to treat hot flashes and vaginal dryness. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. It is an estrogen receptor agonist.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
(+)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. This component has camphoraceous fragrance. (+)-Fenchone is used as a food flavour and in perfumes. Although, there are report that (+)-fenchone has toxic. P450 enzymes are shown to detoxify and/or toxify these compounds to metabolites more polar and sometimes more reactive metabolites. (+)-fenchone are oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives in human liver microsomes. CYP2A6 is suggested to be a principal enzyme in catalyzing (+)-fenchone 6-exo and 6-endo hydroxylation by human liver microsomes. 10-Hydroxylation of (+)-fenchone is also metabolized by CYP2B6.
Status:
Possibly Marketed Outside US
Source:
Butixocort by Onbio Inc.
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Butixocort, also known as tixocortol butyrate, is a synthetic locally acting thioester-linked corticosteroid glucocorticoid corticosteroid with potent anti-inflammatory activity developed by Jouveinal for treatment Allergic rhinitis and Asthma. Butixocort characterized by a large dissociation between it’s local and systemic effects; Butixocorts low or nonexistent glucocorticoid side effects are explained by its high systemic metabolic clearance. The dissociation between local activity and systemic side effects of Butixocorts has been found to be between 100 and 1000 times higher than those of beclomethasone dipropionate and budesonide.
Status:
Possibly Marketed Outside US
Source:
NCT04503460: Phase 4 Interventional Recruiting Asthma
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Fluticasone is a medium-potency synthetic trifluorinated corticosteroid which is used in some countries to manage nasal symptoms of allergic and non-allergic rhinitis. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Both the furoate and propanoate esters, fluticasone furoate and fluticasone propionate, are much more commonly used as topical anti-inflammatories and inhaled corticosteroids.
Status:
Investigational
Source:
NCT00259259: Not Applicable Interventional Completed Obesity
(2005)
Source URL:
Class:
MIXTURE
Status:
Other
Class:
MIXTURE
