Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C27H36O6 |
Molecular Weight | 456.5711 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 6 / 6 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H](OC(=O)CC)[C@H](OC(=O)CC)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(OC(=O)CC)C=C4
InChI
InChIKey=ONMZMZJEZHMWQL-REUUDLSRSA-N
InChI=1S/C27H36O6/c1-5-23(28)31-17-9-11-18-16(14-17)8-10-20-19(18)12-13-27(4)21(20)15-22(32-24(29)6-2)26(27)33-25(30)7-3/h9,11,14,19-22,26H,5-8,10,12-13,15H2,1-4H3/t19-,20-,21+,22-,26+,27+/m1/s1
DescriptionSources: http://www.drugbank.ca/drugs/DB04573Curator's Comment: Description was created based on several sources, including http://www.genome.jp/dbget-bin/www_bget?dr:D01986
Sources: http://www.drugbank.ca/drugs/DB04573
Curator's Comment: Description was created based on several sources, including http://www.genome.jp/dbget-bin/www_bget?dr:D01986
Estriol tripropionate (brand name Estriel), or estriol tripropanoate, is semisynthetic, steroidal estrogen. Estriol is a safe estrogen hormone that has been used for decades in Europe to treat hot flashes and vaginal dryness. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. It is an estrogen receptor agonist.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL206 Sources: http://www.drugbank.ca/drugs/DB04573 |
|||
Target ID: GO:0030252 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3095099 |
250.0 pM [EC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Ovestin 1 mg cream Approved UseOvestin Cream is used:
• For vaginal problems caused by having too little ‘oestrogen’
• Before or after vaginal surgery to help wound healing. Launch Date1982 |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.medicines.org.uk/emc/medicine/28873
Curator's Comment: Also can be used orally http://www.virginiahopkinstestkits.com/estriolhormone.html
ESTRIOL TRIPROPIONATE (Estriol) contains 1mg estriol in 1g cream.
Use the applicator to apply the cream in the vagina.
The applicator has a ring marked on the body. Fill the applicator up to the ring mark with Ovestin cream to get the correct dose.
1. Remove the cap from the tube and turn it upside down. Then use the sharp point to open the tube.
2. Screw the end of the applicator onto the tube.
3. Squeeze the tube to fill the applicator with the cream up to the red ring mark (the plunger will stop at the ring mark).
4. Unscrew applicator from the tube and put the cap back on the tube.
5. To apply the cream, lie down, put the end of the applicator deep into the vagina and slowly push plunger all the way in.
Route of Administration:
Vaginal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26759534
Incubation of the neutrophils in HBSS both with 30 nM Estriol (Estriol tripropionate) resulted in the synthesis of 1.8 ngm maspin with simultaneous increase of NO synthesis
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Estriol tripropionate
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300000039875
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S2A0P1AFQ9
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102232
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DB14641
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218-798-6
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CHEMBL193482
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2236-31-9
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DTXSID4057689
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SUBSTANCE RECORD