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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H26O3
Molecular Weight 326.4293
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESTRONE PROPIONATE

SMILES

[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(OC(=O)CC)C=C4

InChI

InChIKey=ROFBJLDRYQWJFI-WIRSXHRWSA-N
InChI=1S/C21H26O3/c1-3-20(23)24-14-5-7-15-13(12-14)4-6-17-16(15)10-11-21(2)18(17)8-9-19(21)22/h5,7,12,16-18H,3-4,6,8-11H2,1-2H3/t16-,17-,18+,21+/m1/s1

HIDE SMILES / InChI
Estrone, the metabolite of estradiol, is used alone or in combination with other natural estrogens, in the form of ester (acetate, propionate~ or as hydrosoluble conjugate (sodium or piperazine sulphate) in the substitutive hormonal therapy (hypoestrogenic) and in the prevention of the bone loss in the cases of post-menopausal osteoporosis or in oophorectomized women.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
7.0 nM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Estrone

Approved Use

Menopausal hormone replacement therapy, Prophylaxis of osteoporosis
Primary
Estragyn

Approved Use

Estragyn Vaginal Cream is prescribed in the treatment of menopausal and post menopausal symptoms.
PubMed

PubMed

TitleDatePubMed
[High pressure liquid chromatography of corticosteroids: I. Preliminary report of the determinations of plasma corticosterone by HPLC combined with radioimmunoassay (author's transl)].
1977 Jun 20
Patents

Sample Use Guides

Oral Menopausal hormone replacement therapy, Prophylaxis of osteoporosis Adult: 1.4-2.8 mg daily in a cyclical or continuous regimen, usually given with estradiol and estriol. Cyclical progestogen should be given for 12-14 days of each cycle in women with intact uterus.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
ESTRONE PROPIONATE
MI  
Common Name English
ESTRA-1,3,5(10)-TRIEN-17-ONE, 3-(1-OXOPROPOXY)-
Systematic Name English
ESTRONE, PROPIONATE
Common Name English
ESTRONE PROPIONATE [MI]
Common Name English
Code System Code Type Description
PUBCHEM
54277166
Created by admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
PRIMARY
CAS
975-64-4
Created by admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
PRIMARY
FDA UNII
1115H7M5RE
Created by admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
PRIMARY
MERCK INDEX
m5033
Created by admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
PRIMARY Merck Index