Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H26O3 |
| Molecular Weight | 326.4293 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(OC(=O)CC)C=C4
InChI
InChIKey=ROFBJLDRYQWJFI-WIRSXHRWSA-N
InChI=1S/C21H26O3/c1-3-20(23)24-14-5-7-15-13(12-14)4-6-17-16(15)10-11-21(2)18(17)8-9-19(21)22/h5,7,12,16-18H,3-4,6,8-11H2,1-2H3/t16-,17-,18+,21+/m1/s1
| Molecular Formula | C21H26O3 |
| Molecular Weight | 326.4293 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Estrone, the metabolite of estradiol, is used alone or in combination with other natural estrogens, in the form of ester (acetate, propionate~ or as hydrosoluble conjugate (sodium or piperazine sulphate) in the substitutive hormonal therapy (hypoestrogenic) and in the prevention of the bone loss in the cases of post-menopausal osteoporosis or in oophorectomized women.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL206 |
7.0 nM [EC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Estrone Approved UseMenopausal hormone replacement therapy, Prophylaxis of osteoporosis |
|||
| Primary | Estragyn Approved UseEstragyn Vaginal Cream is prescribed in the treatment of menopausal and post menopausal symptoms. |
Sample Use Guides
Oral
Menopausal hormone replacement therapy, Prophylaxis of osteoporosis
Adult: 1.4-2.8 mg daily in a cyclical or continuous regimen, usually given with estradiol and estriol. Cyclical progestogen should be given for 12-14 days of each cycle in women with intact uterus.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:33:15 GMT 2023
by
admin
on
Sat Dec 16 08:33:15 GMT 2023
|
| Record UNII |
1115H7M5RE
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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975-64-4
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admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
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1115H7M5RE
Created by
admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
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m5033
Created by
admin on Sat Dec 16 08:33:15 GMT 2023 , Edited by admin on Sat Dec 16 08:33:15 GMT 2023
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PRIMARY | Merck Index |