Butixocort, also known as tixocortol butyrate, is a synthetic locally acting thioester-linked corticosteroid glucocorticoid corticosteroid with potent anti-inflammatory activity developed by Jouveinal for treatment Allergic rhinitis and Asthma. Butixocort characterized by a large dissociation between it’s local and systemic effects; Butixocorts low or nonexistent glucocorticoid side effects are explained by its high systemic metabolic clearance. The dissociation between local activity and systemic side effects of Butixocorts has been found to be between 100 and 1000 times higher than those of beclomethasone dipropionate and budesonide.