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Restrict the search for
piperonyl butoxide
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2011)
Source URL:
First approved in 1972
Source:
21 CFR 333A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Tert-Butyl alcohol (TBA), also called tert-butanol, an important intermediate in industrial chemical synthesis, is poorly absorbed through skin, but is rapidly absorbed upon inhalation or ingestion and distributed to tissues throughout the body. There is no much information related to the toxicity and pharmacological properties of tert-butanol in humans and animals. However, the recently published article has shown that TBA-associated non-neoplastic and neoplastic histopathological changes in the rat's kidney could be explained by alpha2u-globulin nephropathy (α2u-gN) or enhanced chronic progressive nephropathy (CPN), neither of which are relevant to humans.
Status:
Possibly Marketed Outside US
Source:
ANDA084285
(1950)
Source URL:
First approved in 1950
Source:
ANDA084285
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Sodium butoxide (Sodium butanolate) is used in wide range of applications in organic synthesis; agrochemicals; pharmaceuticals, colorants and aroma chemicals. It can also be used in manufacturing detergents, as a catalyst in polymerization and isomerizations.
Status:
Possibly Marketed Outside US
Source:
NCT01507922: Phase 4 Interventional Completed Irritable Bowel Syndrome
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Fenoverine is a potent musculotropic, the anti-spasmodic agent that restores smooth muscle motility and relieves the distressing symptoms associated with irritable bowel syndrome (IBS) and primary dysmenorrhea. Fenoverine is a non-anticholinergic phenothiazine derivative that may also inhibit calcium channel currents. Fenoverine primarily affects the gastrointestinal tract, bile duct, and female genital organs. Fenoverine has been repeatedly implicated in the occurrence of rhabdomyolysis, a potentially fatal adverse effect, in France. Thes drug has been therefore unavailable in France since December 1995 but commonly used in the treatment of gastrointestinal spasmodic disorders in Taiwan.
Status:
Possibly Marketed Outside US
Source:
Pifazin by Pierrel [Italy]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
PIFARNINE is a non-anticholinergic gastric antisecretory drug used as anti-ulcer agent.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Niperotidine is an H2 antagonist structurally related to ranitidine. H2 antagonists inhibit gastric acid secretion by selectively blocking histamine receptor type 2. Niperotidine was proposed for the treatment of peptic ulcer. Bedtime dose of niperotidine inhibits nocturnal gastric acid secretion in healthy subjects. The duration of niperotidine action was 5 to 7 hours. Twenty-five cases of acute hepatitis (including one death from fulminant hepatitis) associated with niperotidine use were reported in Italy between March and August 1995 and drug was withdrawn from the market. The methylenedioxy group of niperotidine is known to undergo metabolism to catechol and quinone metabolites.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Piribedil is an antiparkinsonian agent which acts as D2 and D3 receptor agonist. In European countries and worldwide it is used as a monotherapy or in combination with dopatherapy for treatment of Parkinson's disease, cognitive impairment and obliterating arteriopathy.
Status:
US Approved OTC
Source:
21 CFR 358.610 pediculicide pyrethrum extract
Source URL:
First marketed in 1921
Class:
MIXTURE
Status:
US Approved Rx
(2008)
Source:
NDA022009
(2008)
Source URL:
First approved in 1993
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium, chemical formula TiO
2. When used as a pigment, it is called titanium white, Pigment White 6 (PW6), or CI 77891. Generally it is sourced from ilmenite, rutile and anatase. It has a wide range of applications, from paint to sunscreen to food coloring. When used as a food coloring, it has E number E171. World production in 2014 exceeded 9 million metric tons. Titanium dioxide has excellent ultraviolet (UV) resistant qualities and acts as a UV absorbent. In the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups. In the cosmetics industry, it is used in toothpaste, lipsticks, creams, ointments and powders. It can be used as an opacifier to make pigments opaque. The FDA has approved the safety of titanium dioxide for use as a colorant in food, drugs and cosmetics, including sunscreens. However, controversy exists as to the safety of titanium dioxide nanoparticles used in the cosmetics industry, for example in sunscreens. Titanium and zinc oxides may be made into the nanoparticle size (0.2-100 nanometers) to reduce the white appearance when applied topically, but retain the UV blocking properties. Recent studies suggest titanium dioxide nanoparticles may be toxic, although further research is needed.
Class (Stereo):
CHEMICAL (ACHIRAL)
Oxmetidine is an H2-receptor antagonist that was studied as a gastrointestinal agent. Oxmetidine possesses efficacy in the treatment of peptic ulcers. However, information about the further development of this drug is not available.
Class (Stereo):
CHEMICAL (ACHIRAL)
Oxmetidine is an H2-receptor antagonist that was studied as a gastrointestinal agent. Oxmetidine possesses efficacy in the treatment of peptic ulcers. However, information about the further development of this drug is not available.
