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Details

Stereochemistry ACHIRAL
Molecular Formula C19H21N5O3S.2CH4O3S
Molecular Weight 591.678
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXMETIDINE MESYLATE

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.CC1=C(CSCCNC2=NC(=O)C(CC3=CC4=C(OCO4)C=C3)=CN2)N=CN1

InChI

InChIKey=KSTYTCDFRHRFLH-UHFFFAOYSA-N
InChI=1S/C19H21N5O3S.2CH4O3S/c1-12-15(23-10-22-12)9-28-5-4-20-19-21-8-14(18(25)24-19)6-13-2-3-16-17(7-13)27-11-26-16;2*1-5(2,3)4/h2-3,7-8,10H,4-6,9,11H2,1H3,(H,22,23)(H2,20,21,24,25);2*1H3,(H,2,3,4)

HIDE SMILES / InChI

Description

Oxmetidine is an H2-receptor antagonist that was studied as a gastrointestinal agent. Oxmetidine possesses efficacy in the treatment of peptic ulcers. However, information about the further development of this drug is not available.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findings.
2010-12
Mechanism of inhibition of rat liver mitochondrial respiration by oxmetidine, an H2-receptor antagonist.
1990-03
Oxmetidine in the short term treatment of active duodenal ulcer. A review and commentary.
1989
Mechanism of oxmetidine (SK&F 92994) cytotoxicity in isolated rat hepatocytes.
1985-06

Sample Use Guides

In Vitro Use Guide
Oxmetidine (50 microM) blocked pyruvate/malate-supported state 3 (ADP-stimulated) respiration, caused a decrease in the ADP:0 ratio and a loss of respiratory control in isolated rat liver mitochondria.
Name Type Language
SK&F 92994-J2
Preferred Name English
OXMETIDINE MESYLATE
USAN  
USAN  
Official Name English
OXMETIDINE MESYLATE [USAN]
Common Name English
SKF-92994-J2
Code English
4(1H)-PYRIMIDINONE, 5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-((2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)AMINO)-, DIMETHANESULFONATE
Systematic Name English
4(1H)-PYRIMIDINONE, 5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-((2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)AMINO)-, DIMETHANESULPHONATE
Systematic Name English
2-((2-(((5-METHYLIMIDAZOL-4-YL)METHYL)THIO)ETHYL)AMINO)-5-PIPERONYL-4(1H)-PYRIMIDINONE DIMETHANESULPHONATE
Systematic Name English
2-[[2-[[(5-Methylimidazol-4-yl)methyl]thio]ethyl]amino]-5-piperonyl-4(1H)-pyrimidinone dimethanesulfonate
Systematic Name English
4(3H)-PYRIMIDINONE, 5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-((2-(((4-METHYL-1H-IMIDAZOL-5-YL)METHYL)THIO)ETHYL)AMINO)-, METHANESULFONATE (1:2)
Systematic Name English
OXMETIDINE MESILATE
Common Name English
SK&F-92994-J2
Code English
Code System Code Type Description
NCI_THESAURUS
C166913
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
FDA UNII
6804GYV3YS
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
CAS
84455-52-7
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
EPA CompTox
DTXSID401004718
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
ChEMBL
CHEMBL2110657
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
USAN
U-61
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
SMS_ID
300000055566
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
PUBCHEM
13186930
Created by admin on Mon Mar 31 17:56:55 GMT 2025 , Edited by admin on Mon Mar 31 17:56:55 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of OXMETIDINE
SUBSTANCE RECORD
Structure of OXMETIDINE MESYLATE
NIH
NCATS
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