OXMETIDINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H21N5O3S.2ClH
Molecular Weight	472.389
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CC1=C(CSCCNC2=NC(=O)C(CC3=CC=C4OCOC4=C3)=CN2)N=CN1

InChI

InChIKey=RBNMEHBTDUJJJM-UHFFFAOYSA-N

InChI=1S/C19H21N5O3S.2ClH/c1-12-15(23-10-22-12)9-28-5-4-20-19-21-8-14(18(25)24-19)6-13-2-3-16-17(7-13)27-11-26-16;;/h2-3,7-8,10H,4-6,9,11H2,1H3,(H,22,23)(H2,20,21,24,25);2*1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2861279 | https://www.ncbi.nlm.nih.gov/pubmed/2575788

Oxmetidine is an H2-receptor antagonist that was studied as a gastrointestinal agent. Oxmetidine possesses efficacy in the treatment of peptic ulcers. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Oxmetidine in the short term treatment of active duodenal ulcer. A review and commentary.	1989	2575788

Sample Use Guides

In Vitro Use Guide

Oxmetidine (50 microM) blocked pyruvate/malate-supported state 3 (ADP-stimulated) respiration, caused a decrease in the ADP:0 ratio and a loss of respiratory control in isolated rat liver mitochondria.

Name

Type

Language

OXMETIDINE HYDROCHLORIDE

Official Name

English

2-[[2-[[(5-Methylimidazol-4-yl)methyl]thio]ethyl]amino]-5-piperonyl-4(1H)-pyrimidinone dihydrochloride

Systematic Name

English

SK&F-92994-A2

Code

English

4(1H)-PYRIMIDINONE, 5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-((2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)AMINO)-, DIHYDROCHLORIDE

Common Name

English

SK&F 92994-A2

Code

English

SK&F 92994-A(SUB 2)

Code

English

SKF-92994-A2

Code

English

OXMETIDINE HCL

Common Name

English

OXMETIDINE HYDROCHLORIDE [USAN]

Common Name

English

Code System Code Type Description

PUBCHEM

162998