TERT-BUTYL ALCOHOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H10O
Molecular Weight	74.1216
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)O

InChI

InChIKey=DKGAVHZHDRPRBM-UHFFFAOYSA-N

InChI=1S/C4H10O/c1-4(2,3)5/h5H,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30590081 | https://www.ncbi.nlm.nih.gov/pubmed/20722584

Tert-Butyl alcohol (TBA), also called tert-butanol, an important intermediate in industrial chemical synthesis, is poorly absorbed through skin, but is rapidly absorbed upon inhalation or ingestion and distributed to tissues throughout the body. There is no much information related to the toxicity and pharmacological properties of tert-butanol in humans and animals. However, the recently published article has shown that TBA-associated non-neoplastic and neoplastic histopathological changes in the rat's kidney could be explained by alpha2u-globulin nephropathy (α2u-gN) or enhanced chronic progressive nephropathy (CPN), neither of which are relevant to humans.

Approval Year

PubMed

Title	Date	PubMed
Oxidation of polycyclic aromatic hydrocarbons by ozone in the presence of sand.	2001	11379152
Evaluation of standard methods for the analysis of methyl tert-butyl ether and related oxygenates in gasoline-contaminated groundwater.	2001 Apr 1	11348088
Microbial degradation and fate in the environment of methyl tert-butyl ether and related fuel oxygenates.	2001 Aug	11549000
Cosolvent effects of alcohols on the Henry's law constant and aqueous solubility of tetrachloroethylene (PCE).	2001 Aug	11513401
Preparation of deacetyl-, lyso-, and deacetyl-lyso-GM(3) by selective alkaline hydrolysis of GM3 ganglioside.	2001 Aug	11483634
High levels of monoaromatic compounds limit the use of solid-phase microextraction of methyl tert-butyl ether and tert-butyl alcohol.	2001 Aug 1	11506001
Absolute kinetic characterization of 17-beta-estradiol as a radical-scavenging, antioxidant synergist.	2001 Aug 15	11488597
Group 4 dimethylmetallocenes: improved synthesis and reactivity studies.	2001 Dec 17	11735467
Enzymatic acylation of hydroxypropyl cellulose in organic media and determination of ester formation by diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy.	2001 Feb 20	11180070
Synthesis of 2,3-dihydroindoles, indoles, and anilines by transition metal-free amination of aryl chlorides.	2001 Feb 23	11312973
Photolysis of polycyclic aromatic hydrocarbons in water.	2001 Jan	11257878
Guanine versus deoxyribose damage in DNA oxidation mediated by vanadium(IV) and vanadium(V) complexes.	2001 Jan	11191217
Palladium-catalyzed amination of aryl bromides and aryl triflates using diphosphane ligands: a kinetic study.	2001 Jan 19	11271534
Photooxidative damage of guanine in DG and DNA by the radicals derived from the alpha cleavage of the electronically excited carbonyl products generated in the thermolysis of alkoxymethyl-substituted dioxetanes and the photolysis of alkoxyacetones.	2001 Jan 26	11429836
Generation and trapping of a highly strained bicyclic alkyne: tricyclo[6.3.1.0(2,7)]dodeca-2,4,6-trien-9-yne.	2001 Jun 1	11375001
tert-Butoxyl as a model for radicals in biological systems: caveat emptor.	2001 Jun 20	11403618
Toxicokinetics of human exposure to methyl tertiary-butyl ether (MTBE) following short-term controlled exposures.	2001 Mar-Apr	11409007
Enhancement of enzyme activity through three-phase partitioning: crystal structure of a modified serine proteinase at 1.5 A resolution.	2001 May	11438752
Anaerobic degradation of methyl tert-butyl ether (MTBE) and tert-butyl alcohol (TBA).	2001 May 1	11355193
Novel synthesis of 4,5-diarylphenanthrenes via C2-C6 cyclization of benzannulated enyne-allenes.	2001 Nov 16	11701039
A new entry to oxacycles via base-catalyzed endo mode cyclization of allenyl sulfoxides and sulfones.	2001 Oct 18	11594840
A DNA oligonucleotide-hemin complex cleaves t-butyl hydroperoxide through a homolytic mechanism.	2001 Sep 10	11531452
Use of pure t-butanol as a solvent for freeze-drying: a case study.	2001 Sep 11	11532568
Oxygen capture by lithiated organozinc reagents containing aromatic 2-pyridylamide ligands.	2001 Sep 3	11575770
Homogeneous degradation of 1,2,9,10-tetrachlorodecane in aqueous solutions using hydrogen peroxide, iron and UV light.	2002 Apr	11996156
Freeze-drying of tert-butanol/water cosolvent systems: a case report on formation of a friable freeze-dried powder of tobramycin sulfate.	2002 Apr	11948553
Decomposition of hydrogen peroxide and organic compounds in the presence of dissolved iron and ferrihydrite.	2002 Apr 1	11999052
SmI(2)-mediated cyclizations of derivatized beta-lactams for the highly diastereoselective construction of functionalized prolines.	2002 Apr 19	11950281
Selective permeation and organic extraction of recombinant green fluorescent protein (gfpuv) from Escherichia coli.	2002 Apr 24	11972900
Synthesis, characterization, and reactivity of monomeric, arylpalladium halide complexes with a hindered phosphine as the only dative ligand.	2002 Aug 14	12167009
Dimethylformamide as a carbon monoxide source in fast palladium-catalyzed aminocarbonylations of aryl bromides.	2002 Aug 23	12182668
Synthesis and catalytic application of octahedral lewis base adducts of dichloro and dialkyl dioxotungsten(VI).	2002 Aug 26	12184764
Base promoted air oxidation of 13beta-ethyl-11-methylenegon-4-en-17-one.	2002 Feb	11755175
Comparative efficiencies of isopropyl and tert-butyl alcohols for extracting zeins from maize endosperm.	2002 Jul 3	12083896
Influence of oxygenated fuel additives and their metabolites on the binding of a convulsant ligand of the gamma-aminobutyric acid(A) (GABA(A)) receptor in rat brain membrane preparations.	2002 Mar 28	11888705
Molecular imprinting of enzymes with water-insoluble ligands for nonaqueous biocatalysis.	2002 May 15	11996551
Rearrangement pathways of 2-hydroxy-2-methylpropylidene: an experimental and computational study.	2002 May 17	12003533

Patents

Name

Type

Language

TERT-BUTYL ALCOHOL

Systematic Name

English

2-METHYL-2-PROPANOL

Systematic Name

English

T-BUTYL ALCOHOL [HSDB]

Common Name

English

BUTYL ALCOHOL, TERT-

Systematic Name

English

T-BUTYL ALCOHOL

Official Name

English

T-BUTYL ALCOHOL [INCI]

Common Name

English

TRIMETHYL CARBINOL

Systematic Name

English

TERTIARY BUTANOL

Common Name

English

TERT-BUTYL ALCOHOL [MI]

Common Name

English

TERT-BUTANOL

Systematic Name

English

TERT-BUTYL ALCOHOL [II]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

1505