U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 21 - 30 of 38 results

Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(1''R)-1''-epi-Perindopril is an epimer of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. (1''R)-1''-epe-Perindopril has configuration S, SS, SR and is less active than the parent drug.
Perindoprilat is a metabolite of perindopril. Perindopril is a long-acting angiotensin converting enzyme (ACE) inhibitor and it is used to treat high blood pressure, heart failure or stable coronary artery disease. Perindopril is designed to allow oral administration as perindoprilat is poorly absorbed from the gastrointestinal tract.
Perindoprilat is a metabolite of perindopril. Perindopril is a long-acting angiotensin converting enzyme (ACE) inhibitor and it is used to treat high blood pressure, heart failure or stable coronary artery disease. Perindopril is designed to allow oral administration as perindoprilat is poorly absorbed from the gastrointestinal tract.
Perindoprilat is a metabolite of perindopril. Perindopril is a long-acting angiotensin converting enzyme (ACE) inhibitor and it is used to treat high blood pressure, heart failure or stable coronary artery disease. Perindopril is designed to allow oral administration as perindoprilat is poorly absorbed from the gastrointestinal tract.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)



(±)-3A,7A-di-epi-Perindopril is a mixture of two isomers (S, RR, SS) and (R, SS, RR) each of which is an isomer of the antihypertensive drug perindopril. The first of which has the same activity as the compound while the second one is almost inactive.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


(1''R,3AR)-1'',3A-di-epi-Perindopril is an epimer (S, RS, SR) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active than the parent compound, perindopril.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


(2R,2'R)-2,2'-di-epi-Perindopril is an epimer (R, SS, RS,) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


(2R,7AR)-2,7A-di-epi-Perindopril is an epimer (R, SR, SS) of the drug perindopril which is commonly used to treat high blood pressure, hypertension, heart failure, or stable coronary artery disease. This form of the drug is much less active.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


(±)-1'',2-di-epi-Perindopril is a mixture of two isomers: (S, SS, RR) and (R, RR, SS) which are both epimers of the antihypertensive drug perindopril and almost inactive.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

(±)-2,3A-di-epi-Perindopril is a mixture of two isomers (S, SR, RR) and (R, RS, SS) which are both inactive epimers of the antihypertensive drug perindopril, although the (R, RS, SS) isomer possesses better activity.

Showing 21 - 30 of 38 results