U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H32N2O5
Molecular Weight 368.4678
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PERINDOPRIL

SMILES

CCC[C@H](N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(O)=O)C(=O)OCC

InChI

InChIKey=IPVQLZZIHOAWMC-QXKUPLGCSA-N
InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1

HIDE SMILES / InChI

Description

Perindopril is a pro-drug for perindoprilat, which is a strong ACE inhibitor in human subjects and animals. Perindopril is used as perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (Aceon) to treat hypertension and stable coronary artery disease.

CNS Activity

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Inhibition of angiotensin I-converting enzyme with S 9490: biochemical effects, interspecies differences, and role of sodium diet in hemodynamic effects.
1984 Nov-Dec
Acute haemodynamic effects of perindoprilat in essential hypertension at rest and during exercise.
1989 Aug
Renal effects of perindoprilat, an angiotensin-converting enzyme inhibitor, in the anesthetized dog.
1989 Feb
Pharmacokinetics of perindopril and its metabolites in healthy volunteers.
1990
The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.
1990 Aug
Specific and high affinity binding of perindoprilat, but not of perindopril to blood ACE.
1992 Sep
Amperometric biosensor based on D-aminoacid oxidase for the R-perindopril assay.
2000 May
Identification and determination of selected medicines reducing hypertension by densitometric and gas chromatographic methods.
2001 Sep-Oct
Detection of coronary microvascular disease by means of cardiac scintigraphy.
2002 Feb
Combined therapy with indapamide and perindopril but not perindopril alone reduced the risk for recurrent stroke.
2002 Mar-Apr
Patents
Name Type Language
PERINDOPRIL
INN   MART.   MI   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
(2S,3AS,7AS)-1-((S)-N-((S)-1-CARBOXYBUTYL)ALANYL)HEXAHYDRO-2-INDOLINECARBOXYLIC ACID, 1-ETHYL ESTER
Common Name English
PERINDOPRIL [INN]
Common Name English
1H-INDOLE-2-CARBOXYLIC ACID, 1-(2-((1-(ETHOXYCARBONYL)BUTYL)AMINO)-1-OXOPROPYL)OCTAHYDRO-, (2S-(1(R*(R*)),2.ALPHA.,3A.BETA.,7A.BETA.))-
Common Name English
S-9490
Code English
PERINDOPRIL [WHO-DD]
Common Name English
PERINDOPRIL [MART.]
Common Name English
PERINDOPRIL [VANDF]
Common Name English
MCN-A-2833
Code English
PERINDOPRIL [MI]
Common Name English
PERINDOPRIL [USAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QC09AA04
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-ATC C09BX01
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-ATC C10BX11
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
NDF-RT N0000175562
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-VATC QC09BX01
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
LIVERTOX 763
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
NDF-RT N0000000181
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-VATC QC09BB04
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-VATC QC09BA04
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-ATC C09AA04
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-ATC C09BX02
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-ATC C09BA04
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
WHO-ATC C09BB04
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
Code System Code Type Description
INN
5754
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
LactMed
82834-16-0
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
WIKIPEDIA
PERINDOPRIL
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
EPA CompTox
82834-16-0
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
EVMPD
SUB09730MIG
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
RXCUI
54552
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY RxNorm
NCI_THESAURUS
C72910
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
CAS
82834-16-0
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
ChEMBL
CHEMBL1581
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
IUPHAR
6367
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
MERCK INDEX
M8555
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY Merck Index
MESH
D020913
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY
PUBCHEM
107807
Created by admin on Tue Mar 06 10:54:28 UTC 2018 , Edited by admin on Tue Mar 06 10:54:28 UTC 2018
PRIMARY SWITZERF