Menthyl lactate is derived from menthol, a compound that comes from peppermint oil, or is made synthetically. Menthol has a natural cooling effect, which makes it useful as a topical analgesic to treat skin irritation, pain, itching or sunburn. Despite its cooling benefits, menthol can be a skin irritant. Like menthol, menthyl lactate is cooling, but it causes less skin irritation than menthol. Menthyl lactate also has a refreshing, minty taste. For this reason, some manufacturers use it as a flavoring ingredient. The compound is recommended for use as a flavor in concentrations of 0.005% to 0.2% and in cosmetic and other external products in concentrations ranging from 0.2% to 2.0%. Menthyl lactate is a known compound available e.g. from Haarmann & Reimer GmbH (Germany) under the name FRESCOLAT, Type ML.

Benzocaine is a local anesthetic. It acts by blocking voltage-gated sodium ion channels in nerve endings. Benzocaine is available over-the counter for local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation), otic pain, and as a local anesthetic for surgical or diagnostic procedures. As a spray, benzocaine is used for temporary relief of pain and itching associated with minor burns, sunburn, minor cuts or scrapes, insect bites, or minor skin irritations. Topical application of benzocaine to gums or mouth may cause rare, but serious and potentially fatal adverse effect methemoglobinemia.

Betoxycaine was used as a local anesthetic.

Aliflurane, a halocarbon drug, is an inhalational anesthetic.

Lotucaine is a local anesthetic.

Propanocaine is a benzyl alcohol derivative with local anesthetics activity

Pribecaine (also known as RG-1812 ) is 3-methoxy-benzoic acid derivative patented by Hungarian multinational pharmaceutical and biotech company Richter, Gedeon, Vegyeszeti Gyar Rt. as local anesthetics. Pribecaine inhibited the generation of action potentials in the giant neurons of the mollusk (Lymnaea stagnalis) and prevented the excitatory effect of acetylcholine. During the inhibition of action potential, the rising phase and repolarization were simultaneously damaged, indicating a blockade of both the Na- and K-channels.

Bucricaine is tetrahydroaminoacridine derivative that has been studied as acetylcholinesterase and monoamine oxidase inhibitor. In animal models, Bucricaine shows a wide spectrum of pharmacological properties, which include analgesic, local anesthetic, analeptic, and respiratory stimulant activities.

Midamaline was used as a local anesthetic. Information about the current use of this compound is not available.

Clodacaine is a local anesthetic drug, invented by Cilag AG in the late 1950s.