U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 41 - 50 of 190 results

Status:
Investigational
Source:
INN:hydroxyprocaine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Hydroxyprocaine was invented as a local anesthetic drug that possessed the antibacterial properties. Information about the current use of this drug is not available.
Status:
Investigational
Source:
INN:murocainide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Murocainide is aminoalkoxybenzofuran derivative patented by pharmaceutical company Delalande S. A. for ventricular tachycardia treatment. At 5 mg/kg i.v. in dogs Murocainide reversed ouabain-induced ventricular tachycardia.
Status:
Investigational
Source:
INN:eticyclidine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Eticyclidine (N-ethyl-1-phenylcyclohexylamine) is a phencyclidine derivative exerting nearly the same pharmacological profile as the parent compound. In rodents, it induces stereotypy, ataxia, interoceptive effect and hypothermia.
Status:
Investigational
Source:
INN:cinoctramide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cinoctramide a derivative of cinnamic acid. It was patented in 1967, and was claimed to act on a central nervous system as a harmonious tranquilizer, and possess anti-convulsive properties in the case of chemically or electrically induced cramps. No clinical development of cinoctramide was reported.
Status:
Investigational
Source:
INN:flutomidate [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Flutomidate was studied as a hypnotic agent. Information about the current use of this agent is not available.
Status:
Investigational
Source:
INN:nofecainide
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Nofecainide (RP 30356, nofedone) is a Class I antiarrhythmic agent. RP 30356 blocked the action potential of frog atrial fibres without noticeably altering the resting membrane potential. RP 30356 inhibited the fast sodium conductance without changing the selectivity of the Na channel. The time to peak of the inward current was not significantly altered by the drug whereas the rate of the Na current inactivation pi h was slowed. The steady state inactivation membrane potential relationship of the Na system was shifted toward negative membrane potentials by the drug. The inhibition of the Na conductance by RP 30356 was frequency-dependent. RP 30356 might be effective in the control of cardiac arrhythmias since it mainly decreased the excitability of depolarized fibres.
Status:
Investigational
Source:
INN:leucinocaine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Leucinocaine is the local anaesthetic with actions similar to lignocaine. It has been used by topical application for local pain relief.
Status:
Investigational
Source:
INN:paridocaine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Paridocaine was developed as a local anesthetic. Information about the current use of this drug is not available.
Status:
Investigational
Source:
INN:octacaine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Octacaine was developed as a local anesthetic agent. Information about the current use of this drug is not available.
Status:
Investigational
Source:
INN:elucaine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Elucaine is local anesthetic and anti-ulcerative agent, acting as a gastric muscarinic acetylcholine receptor antagonist.