Pinolcaine is 10-methyl-2-substituted piperidine. Pinolcaine is a local anesthetic.

Teflurane was first used in man in 1960. A series of thirty anesthetics completed in the first six months suggested that the teflurane was essentially non-toxic to the circulatory system and to hepatic and renal function. However, when the drug was given at inspired concentrations of 10 % and above, cardiac arrhythmias appeared, increased in severity and significance and systolic and diastolic blood pressures fell in direct proportion to the concentration given. That is why the further development of the teflurane was terminated.

Rodocaine (R 22.700) is a biochemical that was found to be an effective anesthetic in ophthalmology. This compound is suitable for topical use but can be injected as well. A pharmaceutically acceptable, acid-addition salt of rodocaine can be prepared by reaction of the rodocaine free base with the desired acid. Rodocaine has furthermore been mentioned as a potential anesthetic agent in antimicrobial compositions.

Vincanol is an alkaloid derived from vinca. The drug possesses hypotensive and vasodilating properties which justify its use in cardiovascular therapy. In vitro studies in rats demonstrated that vincanol may act by blocking voltage-gated Na+ channels.

Phencyclidine is an illegal, hallucinogenic drug that was initially used as an anesthetic agent in the 1950s and early 1960s, but was then withdrawn in 1965 because of dissociative hallucinogenic effects that were often disturbing and sometimes severe and prolonged. Phencyclidine is a noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist and glutamate receptor antagonist, but also interacts with other receptor sites, and may have effects with dopamine, opioid and nicotinic receptors. Phencyclidine disrupts the functioning of receptors for the neurotransmitter glutamate, which plays a major role in the perception of pain as well as in learning, memory, and emotion. It also influences the actions of the neurotransmitter dopamine, which causes the euphoria associated with drug use. Phencyclidine overdose deaths may occur after taking a large dose, though many phencyclidine related deaths result from delusions and other psychological consequences of the drug’s use. There have been reports of death due to accidental drowning, leaping from high places, and motor vehicle accidents in addition to violent episodes of self-mutilation, suicides, and homicides.

Roflurane (DA-893) is a fluorinated ether and general inhalation anesthetic. In humans, this compound shows less hypotensive effects than methoxyflurane. Roflurane was never marketed.

Minaxolone, a water-soluble steroid anesthetic that was studied in 1970s/1980s. It is a positive allosteric modulator of the GABAA receptor. This compound was withdrawn before registration due to reported toxicity in rats.

IPRAVACAINE is a long-acting local anesthetic which anesthetic potency is similar to that of bupivacaine. It blocks the open state of human cardiac K+ channels.

Propipocaine (also known as falicaine) is an aromatic ketone derivative with potent local anaesthetic activity. The toxicity of Propipocaine has been worked out in mice. Given intravenously it is 4 times, and subcutaneously 10 times as toxic as procaine. Falicaine is suitable for surface anaesthesia in a concentration of 0.5 to 1 %. Higher concentrations cause irritation or even necrosis.

Quatacaine is a methylpropionanilide derivative patented by Tanabe Seiyaku Co., Ltd. As local anaesthetic.