MINAXOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H43NO3
Molecular Weight	405.6138
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)C[C@@H](N(C)C)[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C[C@H](O)[C@H](C[C@]34C)OCC

InChI

InChIKey=NCGLTZSBTFVVAW-KNXRZYMVSA-N

InChI=1S/C25H43NO3/c1-7-29-22-14-24(3)16(12-21(22)28)8-9-17-19-11-10-18(15(2)27)25(19,4)13-20(23(17)24)26(5)6/h16-23,28H,7-14H2,1-6H3/t16-,17-,18+,19-,20+,21-,22-,23+,24-,25+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C25H43NO3
Molecular Weight	405.6138
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: Yentis Steve, Hirsch Nicholas P., etc., Anaesthesia and Intensive Care A-Z. retrieved from: https://books.google.ru/books?id=M_W-55fYDyAC&pg=RA1-PA381&lpg=RA1-PA381&dq=MINAXOLONE+toxicity+in+rats&source=bl&ots=n5cFZlS1jN&sig=ACfU3U34wXu7ALJOiDeHrLRrrJBp9HGhvg&hl=ru&sa=X&ved=2ahUKEwiB687a9OHiAhVLxKYKHUNHA94Q6AEwC3oECAgQAQ#v=onepage&q=MINAXOLONE%20toxicity%20in%20rats&f=false | https://www.ncbi.nlm.nih.gov/pubmed/15033889

Minaxolone, a water-soluble steroid anesthetic that was studied in 1970s/1980s. It is a positive allosteric modulator of the GABAA receptor. This compound was withdrawn before registration due to reported toxicity in rats.

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:15:44 GMT 2023` Edited by `admin` on `Fri Dec 15 17:15:44 GMT 2023`
Record UNII	737SKC73L0
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MINAXOLONE

Official Name

English

Minaxolone [WHO-DD]

Common Name

English

PREGNAN-20-ONE, 11-(DIMETHYLAMINO)-2-ETHOXY-3-HYDROXY-, (2.BETA.,3.ALPHA.,5.ALPHA.,11.ALPHA.)-

Systematic Name

English

MINAXOLONE [USAN]

Common Name

English

minaxolone [INN]

Common Name

English

11α-(Dimethylamino)-2β-ethoxy-3α-hydroxy-5α-pregnan-20-one

Systematic Name

English

CCI-12923

Code

English

C.C.I. 12923

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C245