NOFECAINIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H24N2O3
Molecular Weight	340.4162
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NC[C@@H](O)CO[C@H]1N(C(=O)C2=C1C=CC=C2)C3=CC=CC=C3

InChI

InChIKey=KUHVZVZAYMLXGA-OXQOHEQNSA-N

InChI=1S/C20H24N2O3/c1-14(2)21-12-16(23)13-25-20-18-11-7-6-10-17(18)19(24)22(20)15-8-4-3-5-9-15/h3-11,14,16,20-21,23H,12-13H2,1-2H3/t16-,20-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H24N2O3
Molecular Weight	340.4162
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6265234 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y

Nofecainide (RP 30356, nofedone) is a Class I antiarrhythmic agent. RP 30356 blocked the action potential of frog atrial fibres without noticeably altering the resting membrane potential. RP 30356 inhibited the fast sodium conductance without changing the selectivity of the Na channel. The time to peak of the inward current was not significantly altered by the drug whereas the rate of the Na current inactivation pi h was slowed. The steady state inactivation membrane potential relationship of the Na system was shifted toward negative membrane potentials by the drug. The inhibition of the Na conductance by RP 30356 was frequency-dependent. RP 30356 might be effective in the control of cardiac arrhythmias since it mainly decreased the excitability of depolarized fibres.

Approval Year

PubMed

Title	Date	PubMed
Determination of nofedone in human serum by electron-capture GLC.	1980 May	7381700
Effect of RP 30356 on the fast inward Na current in frog atrial fibres.	1981 May 8	6265234

Sample Use Guides

In Vivo Use Guide

Dogs: at doses between 1.25 and 5 mg/kg i.v., Nofecainide (nofedone) induces a marked decrease of the rate of ventricular ectopic contractions, wereas sinus rhythm is unchanged.

Route of Administration: Intravenous

In Vitro Use Guide

Nofecainide (RP 30356) (10(-4)M) blocked the action potential without noticeably altering the resting membrane potential.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:00 GMT 2023` Edited by `admin` on `Fri Dec 15 16:12:00 GMT 2023`
Record UNII	07CJN646IN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NOFECAINIDE

Official Name

English

NOFEDONE

Common Name

English

nofecainide [INN]

Common Name

English

3-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2-PHENYLPHTHALIMIDINE

Common Name

English

RP-30356

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C245