LOTUCAINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H29NO2
Molecular Weight	291.4284
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LOTUCAINE

Structure Search

SMILES

CC1=CC=CC=C1OCC(O)CN2C(C)(C)CCC2(C)C

InChI

InChIKey=ALJMIOMYHUNJQX-UHFFFAOYSA-N

InChI=1S/C18H29NO2/c1-14-8-6-7-9-16(14)21-13-15(20)12-19-17(2,3)10-11-18(19,4)5/h6-9,15,20H,10-13H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C18H29NO2
Molecular Weight	291.4284
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://link.springer.com/book/10.1007/978-1-4757-2085-3

Lotucaine is a local anesthetic.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Synthesis and pharmacological evaluation of thiophene analogs of lotucaine.	1987-04	3595838
[Experimental comparison of 2 anesthetics, carbocaine and lotucaine, in dentistry].	1985-06-30	3867522
Derivatives of tetramethylated cyclic amines. 3. Optical isomers of lotucaine: physico-chemical characteristics and pharmacological activities.	1973-11	4801667

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:34:27 GMT 2025` Edited by `admin` on `Wed Apr 02 09:34:27 GMT 2025`
Record UNII	QCA39I2AP7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LOTUCAINE

Official Name

English

MY-33-7 FREE BASE

Preferred Name

English

2,2,5,5-TETRAMETHYL-.ALPHA.-((O-TOLYLOXY)METHYL)-1-PYRROLIDINEETHANOL

Systematic Name

English

lotucaine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C245

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

Code System Code Type Description

EVMPD

SUB08603MIG

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

PRIMARY

MESH

C003612

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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NCI_THESAURUS

C81414

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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SMS_ID

100000082060

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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FDA UNII

QCA39I2AP7

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

PRIMARY

EPA CompTox

DTXSID10866250

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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CAS

52304-85-5

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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ChEMBL

CHEMBL2105177

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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INN

3211

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

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PUBCHEM

212077

Created by admin on Wed Apr 02 09:34:27 GMT 2025 , Edited by admin on Wed Apr 02 09:34:27 GMT 2025

PRIMARY

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ACTIVE MOIETY