U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2171 - 2180 of 42705 results

Status:
Investigational
Source:
INN:diniprofylline
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Diniprofylline is a vasodilator, broncholytic agent and respiratory stimulant used in severe respiratory insufficiencies.
Status:
Investigational
Source:
INN:dipiproverine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Dipiproverine is the spasmolytic agent. It was used as anticholinergic drug.
Status:
Investigational
Source:
INN:diprogulic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Diprogulic acid (Dikegulac) is used as a precursor in vitamin C synthesis. It is plant growth regulator for hedges. Dikegulac is used to differentially kill terminal apices, and it analogously inhibits basic metabolic functions in dividing cells, but not stationary cells, in suspension culture. At the lowest concentrations, dikegulac partially suppresses division of the isolated tobacco protoplasts. Higher concentrations are required to produce visual cytoplasmic damage to the protoplasts, which probably first occurs at the level of the plasmalemma, as the vacuoles can be released intact. Later, tonoplast disruption occurs. It does not inhibit mature leaves.
Status:
Investigational
Source:
INN:miloxacin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Miloxacin, an antibacterial agent that was used in veterinary. This drug was also studied for the treatment of acute intestinitis. Experiments in vitro have shown that this compound exhibited significant activities against Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Proteus vulgaris, and less active against a Pseudomonas aeruginosa infection and inactive at the maximum test doses against a Streptococcus pyogenes infection. Information about the current use of miloxacin is not available.
Status:
Investigational
Source:
NCT00458159: Phase 1 Interventional Terminated Myelodysplastic Syndrome
(2007)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
INN:divabuterol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Divabuterol or terbutaline dipivalate is a prodrug of terbutaline. The half-life of terbutaline dipivalate in human plasma is less than five minutes. Therapeutically, most forms of terbutaline can be used as bronchodilators in antiasthmatic treatment, as smooth muscle relaxants to treat premature labour (uterine relaxant) and for a number of other indications.
Status:
Investigational
Source:
INN:thiotetrabarbital
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Thiotetrabarbital is a thiobarbituric acid derivative patented by "Centre national de la recherche scientifique" as a short-acting anesthetic agent useful in veterinary medicine.
Status:
Investigational
Source:
NCT00426816: Phase 2 Interventional Completed Sleep Initiation and Maintenance Disorders
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:crufomate
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Crufomate is an insecticide and antihelmintic drug which acts by inhibition of acetylcholinesterase. Crufomate was used on or in cattle, sheep, and goats to control internal cattle grubs and external horn flies and cattle lice. Crufomate is administered by injection, oral administration, and spraying. For the treatment of internal helminth parasites, crufomate is administered by the oral drench directly into the rumen.
Status:
Investigational
Source:
INN:picafibrate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Picafibrate is clofibrate derivative. It is a hypocholesteraemic agent. Fibrates reduce plasma triglycerides by inhibiting their hepatic synthesis and increasing their catabolism. These effects are due to activation of peroxisome proliferator-activated receptors (PPAR alpha) and induction of the over-expression of genes containing a peroxisome proliferator response element (PPRE) in their promoter.

Showing 2171 - 2180 of 42705 results