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Restrict the search for
m nalidixic acid
to a specific field?
Class (Stereo):
CHEMICAL (ACHIRAL)
Diclonixin is the analgesic and anti-inflammatory agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Cinfenoac is a chalcone derivative patented by a pharmaceutical company Biorex Laboratories from the UK. The compound is claimed for the treatment of inflammatory and allergic conditions, as well as for the treatment of the ulcerous condition of the gastrointestinal tract.
Class (Stereo):
CHEMICAL (ACHIRAL)
Properidine is an isopropyl analog of pethidine that acts as opioid analgesic.
Class (Stereo):
CHEMICAL (ACHIRAL)
Brallobarbital possessed the sedative and hypnotic properties and was a component of Vesparax that was used to treat sleep disorders. However, was revealed that brallobarbital was responsible for the problems in Vesparax intoxication.
Status:
Investigational
Source:
NCT03504423: Phase 3 Interventional Completed Pancreatic Cancer Metastatic
(2018)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
CPI-613 is a lipoate derivative synthesized to be catalytically inert but to potentially mimic lipoate catalytic intermediates. The drug is in phase II of clinical trials for the treatment of Myelodysplastic syndromes; Pancreatic cancer; Small cell lung cancer; Solid tumors; Bile duct cancer; Acute Myeloid leukemia. The mechanism of CPI-613 action can be explained by (I) inhibition of tumor cell pyruvate dehydrogenase complex (PDC) through activation of pyruvate dehydrogenase kinases leading to inactivating phosphorylation of the E1alpha-subunit of PDC; and (II) inhibition of alpha-ketoglutarate dehydrogenase.
Class (Stereo):
CHEMICAL (RACEMIC)
Guaisteine, a thiazolidine derivative that was used as an antitussive agent. This compound has never been marketed.
Status:
Investigational
Source:
NCT00909688: Phase 1 Interventional Completed Healthy
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
BLI 489 was developed by Wyeth as a 6-methylidene-penem β-lactamase inhibitor for the treatment of bacterial infections and urinary tract infections. BLI-489 has shown the promising clinical data, however, development of this drug, was discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Mepramidil (PF-26) is a coronary vasodilator.
Status:
Investigational
Source:
INN:flavodic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Flavodic acid is a synthetic hydrosoluble derivative of natural flavonoids. It has been shown to reduce capiliary fragility and permeability. Sodium flavodate was marketed by the Italian pharmaceutical company Farmaceutici under tradename Pericel.
Class (Stereo):
CHEMICAL (RACEMIC)
In the early stages of testing was shown that it is about 4 times more potent than gallopamil and 12 times more potent than verapamil in its effects on smooth muscle tone and labeled calcium uptake.
