Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H11F3N2O2S |
Molecular Weight | 376.352 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CN1C=C(CC2=NC3=C(S2)C(F)=CC(F)=C3F)C4=C1C=CC=C4
InChI
InChIKey=KYHVTMFADJNSGS-UHFFFAOYSA-N
InChI=1S/C18H11F3N2O2S/c19-11-6-12(20)18-17(16(11)21)22-14(26-18)5-9-7-23(8-15(24)25)13-4-2-1-3-10(9)13/h1-4,6-7H,5,8H2,(H,24,25)
Lidorestat is a highly potent and selective aldose reductase inhibitor with good oral bioavailability that is reported to improve nerve conduction and reduce cataract formation. Lidorestat reduced mortality rates in hAR transgenic mice. Mice receiving lidorestat had similar survival rates as nonhAR-expressing diabetic mice. Lidorestat treatment did not affect plasma lipids, glucose, or weights of diabetic mice. Drugs such as lidorestat will improve human health by reducing the production of toxic products of the polyol pathway. Lidorestat was developed for the treatment of diabetic complications, including neuropathy, retinopathy, cataracts, nephropathy.
Approval Year
PubMed
Title | Date | PubMed |
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Diabetic cataract-pathogenesis, epidemiology and treatment. | 2010 |
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Identification of new non-carboxylic acid containing inhibitors of aldose reductase. | 2010 Jun 1 |
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High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons. | 2018 Nov |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18974362
Curator's Comment: Mice data
25 mg/kg/day for 6 weeks
Route of Administration:
Oral
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C72880
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)