PICAFIBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H19ClN2O4
Molecular Weight	362.807
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(OC1=CC=C(Cl)C=C1)C(=O)OCCNC(=O)C2=CC=CN=C2

InChI

InChIKey=MCECKJXCBZXVJI-UHFFFAOYSA-N

InChI=1S/C18H19ClN2O4/c1-18(2,25-15-7-5-14(19)6-8-15)17(23)24-11-10-21-16(22)13-4-3-9-20-12-13/h3-9,12H,10-11H2,1-2H3,(H,21,22)

HIDE SMILES / InChI

Description
Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 977, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://apps.who.int/iris/bitstream/handle/10665/68742/WHO_EDM_QSM_2004.5.pdf | Aronson, J.K. (2015) Meyler's Side Effects of Drugs, page 305, retrieved from: https://books.google.ru/books?id=NOKoBAAAQBAJ

Picafibrate is clofibrate derivative. It is a hypocholesteraemic agent. Fibrates reduce plasma triglycerides by inhibiting their hepatic synthesis and increasing their catabolism. These effects are due to activation of peroxisome proliferator-activated receptors (PPAR alpha) and induction of the over-expression of genes containing a peroxisome proliferator response element (PPRE) in their promoter.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor alpha 62 Target ID: CHEMBL239 Sources: https://books.google.ru/books?id=NOKoBAAAQBAJ	Activator 1430

PubMed

Title	Date	PubMed
[Picafibrate. I. Physico-chemical and analytical characteristics].	1977 Sep	145868
[Picafibrate. II. Absorption, distribution and elimination in the rat after labelling with carbon-14].	1981 Feb	6453601

Name

Type

Language

PICAFIBRATE

Official Name

English

picafibrate [INN]

Common Name

English

2-(P-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ESTER WITH N-(2-HYDROXYETHYL)NICOTINAMIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150