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Showing 11 - 20 of 2,893 results

Status:
US Approved Rx (1995)
First approved in 1974

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:


Mebendazole, known as Emverm is a (synthetic) broad-spectrum anthelmintic that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucos...
Status:
US Approved Rx (1978)
First approved in 1972

Class (Stereo):
CHEMICAL (ACHIRAL)


Dimethyl sulfoxide (DMSO) is a clear odorless liquid, inexpensively produced as a by-product of the paper industry. It is widely available in the USA as a solvent but its medical use is currently restricted by the FDA to the palliative treatment of i...
Status:
US Approved Rx (2024)
First approved in 1965

Class (Stereo):
CHEMICAL (ACHIRAL)



Tromethamine is extensively used in biochemistry and molecular biology. Because tromethamine (in the form of R-NH2) is a proton acceptor with a pK of 7.8, it is an effective buffer that can be used to maintain the pH of body fluids. Tromethamine is i...
Status:
US Approved Rx (2022)
First approved in 1963

Class (Stereo):
CHEMICAL (ACHIRAL)



Diazepam is a benzodiazepine first discovered at Hoffman-La Roche in the late 1950s. Diazepam was approved by FDA for the treatment of anxiety disorders as well as for such conditions as skeletal muscle spasm, alcohol withdrawal syndrom and convulsion...
Status:
US Approved Rx (2014)
First approved in 1963

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:


Metronidazole was synthesized by France's Rhone-Poulenc laboratories and introduced in the mid-1950s under the brand name Flagel in the US, while Sanofi-Aventis markets metronidazole globally under the same trade name, Flagyl, and also by various gen...
Status:
US Approved Rx (1987)
First approved in 1961

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Vinblastine is a Vinca alkaloid obtained from the Madagascar periwinkle plant. Vinca alkaloids were found out in the 1950's by Canadian scientists, Robert Noble and Charles Beer for the first time. Medicinal applications of this plant lead to the mon...
Status:
US Approved Rx (1984)
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Chlorhexidine is a broad-spectrum biocide effective against Gram-positive bacteria, Gram-negative bacteria and fungi. It is used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate). Chlorhexidine inactivates microorganisms ...
Status:
US Approved Rx (2007)
First approved in 1959

Class (Stereo):
CHEMICAL (ABSOLUTE)



Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against v...
Status:
US Approved Rx (2013)
First approved in 1956

Class (Stereo):
CHEMICAL (RACEMIC)



Mecamylamine (Inversine), the first orally available antihypertensive agent, is now rarely used. Introduced as a therapeutic agent for the treatment of hypertension in the 1950s, mecamylamine was the first useful ganglionic blocking agent that was no...
Status:
US Approved Rx (2023)
First approved in 1955

Class (Stereo):
CHEMICAL (ACHIRAL)



Dapsone was synthesized in 1908 by Fromm and Wittmann. The drug was approved by FDA for the treatment of such conditions as acne vulgaris, leprosy and dermatitis herpetiformis, also the drug is used off-label for many skin diseases. Although the exac...

Showing 11 - 20 of 2,893 results