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Restrict the search for
vitamin a
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Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Investigational
Source:
NCT02179814: Not Applicable Interventional Suspended Bulimia Nervosa
(2012)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Racemetirosine is an orally active inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamine. At dosages of 600 to 3500mg daily, it is effective in controlling the hypertensive episodes and symptoms of catecholamine excess in phaeochromocytoma during preparation for surgery. Oral Racemetirosine is well absorbed and absorption appears constant in each individual over a wide dosage range. The drug is largely excreted via the kidneys, but extrarenal elimination has not been studied. Case reports on the clinical use of Racemetirosine in phaeochromocytoma indicate that the drug controls hypertension and symptoms of catecholamine excess in most patients during preparation for surgical removal of a tumor. In some cases, the addition of Racemetirosine to phenoxybenzamine plus propranolol has resulted in adequate control of symptoms previously unresponsive to the adrenergic blocking regimen. Drowsiness and sedation have been the most frequently reported side effects of Racemetirosine treatment.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Nicocodine is an opioid related to codeine. It is also an antitussive agent. Nicocodine exhibits at least twice the potency of codeine in clinical experiments. The study of the pharmacokinetic behaviour of nicocodine by means of blood and brain level curves of rats after i .v. application showed that the penetration of the blood
brain barrier seems to be favoured for nicocodine. The detected peak concentration of nicocodine in brain after i.v. application is 4.4 times higher than the blood level values at the same time - codeine the main metabolite is detected in almost equal amounts in brain and blood. A comparative assay of codeine and nicocodine after p.o. application of equimolar doses per kg body weight revealed that predominantly codeine is found in brain and its peak value after nicocodine administration is 3-fold higher than after codeine administration. Nicocodine is hydrolysable to morphine and the WHO Expert Committee on Addiction-Producing Drugs (1962) recommended its international control as a narcotic, like other convertible drugs in the morphine series.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Tanaproget (WAY-166989) is a nonsteroidal progesterone receptor agonist. It has been in Phase-II clinical trials as an oral contraceptive. The compound demonstrated a positive preclinical pharmacological profile in the treatment of endometriosis. The level of progesterone receptors in breast tumours can be used to guide the selection of endocrine therapies for breast cancer patients. Radiolabeled analogues of tanaproget have diagnostic potential as PET imaging agents for breast cancer.
Status:
Investigational
Source:
INN:darbufelone [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Darbufelone mesylate is a dual inhibitor of cellular prostaglandin and leukotriene production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 uM) but is much less potent with PGHS-1 (IC50= 20 uM). Darbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis. Darbufelone mesylate was in phase III clinical trials by Pfizer and Zhuhai United Laboratories for the treatment of rheumatoid arthritis.
Status:
Investigational
Source:
Eur J Heart Fail. Oct 2022;24(10):1967-1977.: Phase 2 Human clinical trial Completed Shock, Cardiogenic/etiology
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Etiocholanone is an androstane neurosteroid. Etiocholanone potentiates GABA-A receptor currents and exerts anticolvunsant properties in rodents. Etiocholanolone demostrates pyrogenic properties.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Octrizole (UV-329) is used as UV stabilizer
within products to increase stability to light. It protects polymers as well as organic pigments from UV radiation helping to preserve the original appearance and physical integrity of polymeric systems; particularly in polyesters, polyvinyl chlorides, styrenics, acrylics, polycarbonates and polyvinyl butyral during outdoor weathering. Octrizole is an indirect additive used in food contact substances. It is
used in cosmetics. The use levels of Octrizole (UV-329) range between 0.10 and 1.0%, depending on substrate
and performance requirements of the final application. The product can be used
alone or in combination with other additives such as light stabilizers (hindered
amines), antioxidants (hindered phenols, phosphites, thiosynergists,
hydroxylamines, benzofuranones), and other functional stabilizers and
additives. The use of UV-329 in combination with hindered amine light stabilizers
is particularly noteworthy in that a synergistic performance is often observed.
Performance data of UV- 329 alone or in combination with other additives are
available in selected substrates.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Demecycline is a tetracycline antibiotic drug. Tetracyclines have a broad spectrum of anti-microbial activity and act by interfering with bacterial protein synthesis. Demecycline is used to treat a wide range of infections caused by bacteria. Some of these infections are: Severe acne; Infections of the brain and liver caused by the bacteria Leptospira; Infection caused by Brucella bacteria (brucellosis); Infections caused by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites; Infections of the sex organs and organs associated with urination (genito-urinary infections) such as an infection called chancroid, non-gonococcal urethritis; Rare infections such as Tularaemia and bubonic plague. The following undesirable effects have been reported for demecycline: loss of appetite, nausea, vomiting, diarrhea, inflammation of the tongue, difficulty in swallowing, intestinal inflammation, and inflammatory lesions, rashes, redness of the skin, pigmentation, sensitivity to light, acute kidney failure and others.
Class (Stereo):
CHEMICAL (ACHIRAL)
Cotriptyline is a tricyclic antidepressant, discovered by French Societe Industrielle pour la Fabrication des Antibiotiques. The compound antagonized reserpine-induced ptosis and bradycardia in rodents and potentiated stereotyped behavior induced by administration of d-amphetamine.
Status:
Investigational
Source:
Tokai J Exp Clin Med. May 1990;15(2-3):123-7.: Not Applicable Human clinical trial Completed Liver Cirrhosis, Alcoholic/physiopathology
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
