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Details

Stereochemistry ACHIRAL
Molecular Formula C20H25N3O
Molecular Weight 323.432
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OCTRIZOLE

SMILES

CC(C)(C)CC(C)(C)C1=CC=C(O)C(=C1)N2N=C3C=CC=CC3=N2

InChI

InChIKey=IYAZLDLPUNDVAG-UHFFFAOYSA-N
InChI=1S/C20H25N3O/c1-19(2,3)13-20(4,5)14-10-11-18(24)17(12-14)23-21-15-8-6-7-9-16(15)22-23/h6-12,24H,13H2,1-5H3

HIDE SMILES / InChI
Octrizole (UV-329) is used as UV stabilizer within products to increase stability to light. It protects polymers as well as organic pigments from UV radiation helping to preserve the original appearance and physical integrity of polymeric systems; particularly in polyesters, polyvinyl chlorides, styrenics, acrylics, polycarbonates and polyvinyl butyral during outdoor weathering. Octrizole is an indirect additive used in food contact substances. It is used in cosmetics. The use levels of Octrizole (UV-329) range between 0.10 and 1.0%, depending on substrate and performance requirements of the final application. The product can be used alone or in combination with other additives such as light stabilizers (hindered amines), antioxidants (hindered phenols, phosphites, thiosynergists, hydroxylamines, benzofuranones), and other functional stabilizers and additives. The use of UV-329 in combination with hindered amine light stabilizers is particularly noteworthy in that a synergistic performance is often observed. Performance data of UV- 329 alone or in combination with other additives are available in selected substrates.

Approval Year

PubMed

PubMed

TitleDatePubMed
Steroid hormone activity of flavonoids and related compounds.
2000 Jul
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Patents

Sample Use Guides

LD50 Rat Oral : > 10000 mg/kg
Route of Administration: Oral
Putative thyroid disrupting effect of UV-329 (Octrizole) was studied in zebrafish embryos at 1, 10 and 100 ug/L for 96 h.
Name Type Language
OCTRIZOLE
INCI   INN   USAN  
USAN   INCI   INN  
Official Name English
octrizole [INN]
Common Name English
OCTRIZOLE [USAN]
Common Name English
BISOCTRIZOLE RELATED COMPOUND A [USP-RS]
Common Name English
OCTRIZOLE [INCI]
Common Name English
PHENOL, 2-(2H-BENZOTRIAZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)-
Systematic Name English
BISOCTRIZOLE RELATED COMPOUND A [USP IMPURITY]
Common Name English
2-(2H-Benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol
Systematic Name English
BISOCTRIZOLE RELATED COMPOUND A
USP-RS  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C851
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
Code System Code Type Description
FDA UNII
R775Y233N3
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INN
4704
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NCI_THESAURUS
C80799
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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ChEMBL
CHEMBL1886986
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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SMS_ID
100000083309
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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RS_ITEM_NUM
1075688
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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EPA CompTox
DTXSID9027522
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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PUBCHEM
62485
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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CAS
3147-75-9
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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EVMPD
SUB09419MIG
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
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ECHA (EC/EINECS)
221-573-5
Created by admin on Fri Dec 15 16:18:22 GMT 2023 , Edited by admin on Fri Dec 15 16:18:22 GMT 2023
PRIMARY