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Restrict the search for
alpha-tocopherol acetate
to a specific field?
Status:
Investigational
Source:
NCT02977234: Phase 1/Phase 2 Interventional Unknown status Hydrosalpinx
(2016)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT01129193: Phase 1 Interventional Completed Adult Nasal Type Extranodal NK/T-cell Lymphoma
(2010)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
AR-42, also known as (S)-HDAC-42, is a phenylbutyrate-based histone deacetylase (HDAC) inhibitor. HDACs are enzymes that determine acetylation status of histones, thereby affecting chromatin structure and regulating the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. AR-42 possesses antitumor activity at multiple cellular levels. It is currently in Phase I/Ib trials for hematological malignancies and solid tumors.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Metoserpate (SU9064) is a sedative drug used in veterinary. PACITRAN (metoserpate hydrochloride) is indicated as a tranquilizer in stressed poultry.
Status:
Investigational
Source:
INN:lortalamine [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Lortalamine is a new non-tricyclic anti-depressant compound. Lortalamine antagonizes in a dose-related manner reserpine-induced ptosis and hypothermia, and is far more potent than imipramine in this regard. The compound potentiates yohimbine toxicity in mice and, in the anesthetized dog, diminishes the tyramine pressure response while increasing the response to norepinephrine. These results would indicate the capacity for lortalamine to act as a norepinephrine uptake inhibitor, and indeed, lortalamine is more potent than imipramine in inhibiting norepinephrine uptake by rat brain cortex slices. Lortalamine does not inhibit serotonin uptake by rat midbrain slices. Lortalamine has a high affinity and high selectivity for the norepinephrine transporter. Lortalamine treated dogs showed, progressively, bilateral mydriasis, conjunctivitis, epiphora, corneal oedema and corneal erosions.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ethynerone (MK 665) is an oral contraceptive steroid. In preclinical studies, it induced mammary tumors.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ciprocinonide (RS-2386) is a synthetic glucocorticoid corticosteroid. It was developed in the 1980s for a topical administration as a component of the Triple Corticoid Integrated System.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Procinonide is a derivative of fluocinolone acetonide that has been applied topically with fluocinonide and ciprocinonide in the management of various skin disorders.
Class (Stereo):
CHEMICAL (ABSOLUTE)
KETAZOCINE, a benzomorphan derivative, is a kappa opioid receptor agonist. It is used in opioid receptor research.
Status:
Investigational
Source:
Diabetes Obes Metab. Mar 2023;25(3):832-843.: Phase 2 Human clinical trial Completed Diabetes Mellitus, Type 2/complications
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Status:
Investigational
Source:
INN:disobutamide [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Disobutamide suppresses ventricular arrhythmias in several in vivo animal models. In particular, disobutamide suppressed ventricular arrhythmias in ouabain-toxic dogs and in dogs in which myocardial infarction. Clear cytoplasmic vacuolation associated with disobutamide is an example of a remarkable morphologic change not associated with apparent overt toxicity based on various functional tests. Clinically in the dog if vacuolation was associated with cell injury, one might expect a chronic debilitating condition as seen in the case of many spontaneous genetic storage diseases. Chronic heart failure or a gastrointestinal motility disorder might occur as a result of the changes in the musculature of coronary arteries or gastrointestinal wall, respectively. Disobutamide, because of its apparent low toxicity, can be recommended as useful for investigations aimed at determining the borderline between physiologic limits and toxicity of intracellular drug storage and for advancing knowledge of mechanisms involved in xenobiotics entry and storage in cells. Disobutamide was withdrawn from clinical testing when clear cytoplasmic vacuoles were found in the rat and dog during toxicity studies. Disobutamide induced vacuoles in all cell types except rat leukaemia. The drug induced cell death and reduction in confluency or cell count in cultures of all cell types except rat carcinoma and rabbit aorta muscle.
