ETHYNERONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H23ClO2
Molecular Weight	330.848
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ETHYNERONE

Structure Search

SMILES

[H][C@@]12CC[C@@](O)(C#CCl)[C@@]1(C)CCC3=C4CCC(=O)C=C4CC[C@@]23[H]

InChI

InChIKey=KEOBKPHJNAILCW-FUMNGEBKSA-N

InChI=1S/C20H23ClO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-9H2,1H3/t17-,18+,19+,20-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3358452 | https://www.ncbi.nlm.nih.gov/pubmed/6930510 | https://www.ncbi.nlm.nih.gov/pubmed/411941 | https://www.ncbi.nlm.nih.gov/pubmed/650701

Ethynerone (MK 665) is an oral contraceptive steroid. In preclinical studies, it induced mammary tumors.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Mammary nodules in beagle dogs administered investigational oral contraceptive steroids.	1978 Jun	650701
The effects of a mixture of mestranol and ethynerone on the female monkey.	1979 Apr	105931
Malignant mammary tumors in beagle dogs dosed with investigational oral contraceptive steroids.	1980 Jul	6930510
Changes in estrogen metabolism after chronic oral contraceptive administration in the rhesus monkey.	1984 Mar-Apr	6144478
The morphologic effects of synthetic reproductive steroids on the mammary gland of rhesus monkeys. Mestranol, ethynerone, mestranol-ethynerone, chloroethynyl norgestrel-mestranol, and anagestone acetate-mestranol combinations.	1988 May	3358452

Name

Type

Language

ETHYNERONE

Official Name

English

ethynerone [INN]

Common Name

English

19-NORPREGNA-4,9-DIEN-20-YN-3-ONE, 21-CHLORO-17-HYDROXY-, (17.ALPHA.)-

Common Name

English

ETHYNERONE [USAN]

Common Name

English

21-Chloro-17-hydroxy-19-nor-17α-pregna-4,9-dien-20-yn-3-one

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C776

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Code System Code Type Description

CAS

3124-93-4

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INN

2038

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ChEMBL

CHEMBL2104303

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PUBCHEM

10336790

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NCI_THESAURUS

C74366

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EVMPD

SUB07293MIG

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MESH

C016442

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EPA CompTox

DTXSID10185170

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SMS_ID

100000082070

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WIKIPEDIA

Ethynerone

Created by admin on Fri Dec 15 15:20:26 UTC 2023 , Edited by admin on Fri Dec 15 15:20:26 UTC 2023

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FDA UNII

CKM4S0R7LX

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ACTIVE MOIETY


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