Cambendazole is a veterinary anti-parasitic drug, which was approved by FDA for the treatment of worm infections in horses. The mode of action of cambendazole is the inhibition of glucose uptake, fumarate reductase and phosphoenolpyruvate carboxykinase. Due to its mechanism of action, cambendazole causes the paralysis of parasites.

Buquiterine is an alkaloid useful as antihypertensives and bronchodilators and in the treatment of allergy

Antienite is a highly potent anthelmintic against nematodes in chickens and sheep. Antienite was also active in rodents but it was expensive and had limited solubility in water. These results led the Janssen pharmaceutical company to develop a close analog tetramisole.

Ticarbodine is as effective broad-spectrum canine anthelmintic. Ticarbodine is effective for the ascarids, hookworms, and tapeworms but not the whipworm of dogs. The drug is used in dogs for the removal of roundworms (Toxocara canis), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis).

Teclozan, an antiprotozoal agent, was used to treat the intestinal amebiasis. Teclozan prevents the formation of arachidonic acid in the parasite by intervening in the phospholipid metabolism.

Bunamidine is a anti-parasitic drug, which was approved by FDA for the treatment of tapeworms in cats and dogs (Scolaban 400 tablets).

Amocarzine is an antifilarial antihelminthic drug, derived from amoscanate, that is active against the adult worms of Onchocerca volvulus. In animal studies of filarial infections, amocarzine showed promise as a macrofilaricidal drug and was afterward extensively tried in humans. Amocrazine has an adverse effects: dizziness, itching and rush. There were reversible neurological symptoms, such as impaired coordination and a positive Romberg’s sign. In a study from Ghana, the combination of ivermectin and amocarzine was not more effective than ivermectine alone and adverse effects were more severe. Amocarzine has no role in the treatment of onchocerciasis in Africa. In silico data emphasize that amocarzine could be potential lead compound that can be further developed into nematicidal chemical against Bursaphelenchus xylophilus.

Abunidazole is the antiprotozoal agent. It has antifungal and antimicrobial activity.

Acetarsone is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties. It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol (fourneau is the French word for stove). Before stovarsol was used in the treatment of congenital syphilis, it had already been used in other diseases : amoebiasis, acquired syphilis, yaws, trypanosomiasis and malaria, and a formidable list of toxic manifestations can be compiled from the literature. Bender (I927) recorded six cases of poisoning with malaise, fever, cedema, jaundice, diarrhoea, albuminuria, bronchitis, coryza and skin troubles, such as diffuse erythema, dryness and pruritus. Of 232 cases of amoebiasis treated by Brown (I935) without a death, thirteen (5.6%) had toxic erythemata, some of them so severe as to amount to exfoliative dermatitis. Although its mechanism of action is not fully known, acetarsone may bind to protein-containing sulfhydryl groups located in the parasite, thereby forming lethal As-S bonds. This may prevent their functioning and eventually kill the parasite.