U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry MIXED
Molecular Formula C15H19F3N2S
Molecular Weight 316.385
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TICARBODINE

SMILES

CC1CCCC(C)N1C(=S)NC2=CC(=CC=C2)C(F)(F)F

InChI

InChIKey=YTNJAWMNFLIDLW-UHFFFAOYSA-N
InChI=1S/C15H19F3N2S/c1-10-5-3-6-11(2)20(10)14(21)19-13-8-4-7-12(9-13)15(16,17)18/h4,7-11H,3,5-6H2,1-2H3,(H,19,21)

HIDE SMILES / InChI
Ticarbodine is as effective broad-spectrum canine anthelmintic. Ticarbodine is effective for the ascarids, hookworms, and tapeworms but not the whipworm of dogs. The drug is used in dogs for the removal of roundworms (Toxocara canis), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis).

Originator

Curator's Comment: # Elanco Animal Health, A Div. of Eli Lilly & Co.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Ticarbodine

Approved Use

The drug is used in dogs for the removal of roundworms (Toxocara canis), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis).
PubMed

PubMed

TitleDatePubMed
Efficacy of single oral doses of ticarbodine against nematodes and cestodes of dogs.
1972 Apr
Critical and clinical evaluation of ticarbodine as a canine anthelmintic.
1972 May
In vitro activity of various anthelmintic compounds against Haemonchus contortus larvae.
1983 Nov
Patents

Sample Use Guides

Dogs: Dosage is administered at 45 milligrams of the drug per pound of body weight in a single dose. Dosage may be repeated in 21 days
Route of Administration: Oral
In Vitro Use Guide
Ticarbodine was active against Haemonchus contortus at a concentration of 100 ug/ cm(-3) or less.
Name Type Language
TICARBODINE
GREEN BOOK   INN   MI   USAN  
USAN   INN  
Official Name English
TICARBODINE [GREEN BOOK]
Common Name English
TICARBODINE [MI]
Common Name English
ticarbodine [INN]
Common Name English
TICARBODINE [USAN]
Common Name English
EL-974
Code English
Classification Tree Code System Code
NCI_THESAURUS C250
Created by admin on Sat Dec 16 15:54:35 GMT 2023 , Edited by admin on Sat Dec 16 15:54:35 GMT 2023
Code System Code Type Description
MESH
C003469
Created by admin on Sat Dec 16 15:54:35 GMT 2023 , Edited by admin on Sat Dec 16 15:54:35 GMT 2023
PRIMARY
SMS_ID
100000082186
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PRIMARY
ChEMBL
CHEMBL2104761
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PRIMARY
INN
3023
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PRIMARY
EPA CompTox
DTXSID40865615
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PRIMARY
EVMPD
SUB11026MIG
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PRIMARY
MERCK INDEX
m966
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PRIMARY Merck Index
CAS
31932-09-9
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PRIMARY
NCI_THESAURUS
C75234
Created by admin on Sat Dec 16 15:54:35 GMT 2023 , Edited by admin on Sat Dec 16 15:54:35 GMT 2023
PRIMARY
FDA UNII
J4CLF34O60
Created by admin on Sat Dec 16 15:54:35 GMT 2023 , Edited by admin on Sat Dec 16 15:54:35 GMT 2023
PRIMARY
PUBCHEM
3034015
Created by admin on Sat Dec 16 15:54:35 GMT 2023 , Edited by admin on Sat Dec 16 15:54:35 GMT 2023
PRIMARY