TICARBODINE

Possibly Marketed Outside US

Details

Stereochemistry	MIXED
Molecular Formula	C15H19F3N2S
Molecular Weight	316.385
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CCCC(C)N1C(=S)NC2=CC=CC(=C2)C(F)(F)F

InChI

InChIKey=YTNJAWMNFLIDLW-UHFFFAOYSA-N

InChI=1S/C15H19F3N2S/c1-10-5-3-6-11(2)20(10)14(21)19-13-8-4-7-12(9-13)15(16,17)18/h4,7-11H,3,5-6H2,1-2H3,(H,19,21)

HIDE SMILES / InChI

Description
Sources: http://bionames.org/bionames-archive/issn/0018-0130/43/135.pdf | https://www.gpo.gov/fdsys/pkg/CFR-2000-title21-vol6/pdf/CFR-2000-title21-vol6-sec520-2455.pdf

Ticarbodine is as effective broad-spectrum canine anthelmintic. Ticarbodine is effective for the ascarids, hookworms, and tapeworms but not the whipworm of dogs. The drug is used in dogs for the removal of roundworms (Toxocara canis), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis).

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Toxocara canis 1 Target ID: Toxocara canis Sources: http://bionames.org/bionames-archive/issn/0018-0130/43/135.pdf	Inhibitor 8504
Taenia pisiformis 1 Target ID: CHEMBL612340 Sources: http://bionames.org/bionames-archive/issn/0018-0130/43/135.pdf	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis in dogs 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5062900 https://www.ncbi.nlm.nih.gov/pubmed/5023048	Curative		Approved 8583	Ticarbodine Approved Use The drug is used in dogs for the removal of roundworms (Toxocara canis), hookworms (Ancylostoma caninum and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis).

PubMed

Title	Date	PubMed
In vitro activity of various anthelmintic compounds against Haemonchus contortus larvae.	1983-11	6686387
Critical and clinical evaluation of ticarbodine as a canine anthelmintic.	1972-05	5023048
Efficacy of single oral doses of ticarbodine against nematodes and cestodes of dogs.	1972-04	5062900

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: Dosage is administered at 45 milligrams of the drug per pound of body weight in a single dose. Dosage may be repeated in 21 days

Route of Administration: Oral

In Vitro Use Guide

Ticarbodine was active against Haemonchus contortus at a concentration of 100 ug/ cm(-3) or less.

Name

Type

Language

TICARBODINE

Official Name

English

EL-974

Preferred Name

English

TICARBODINE [GREEN BOOK]

Common Name

English

TICARBODINE [MI]

Common Name

English

ticarbodine [INN]

Common Name

English

TICARBODINE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250