ANTIENITE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H8N2S2
Molecular Weight	208.303
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1C(N=C2SC=CN12)C3=CC=CS3

InChI

InChIKey=RFOLEEQBNNSICL-UHFFFAOYSA-N

InChI=1S/C9H8N2S2/c1-2-8(12-4-1)7-6-11-3-5-13-9(11)10-7/h1-5,7H,6H2

HIDE SMILES / InChI

Molecular Formula	C9H8N2S2
Molecular Weight	208.303
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://kuls-ir.kuvempu.ac.in/1603/1/t-2922.pdf | https://www.ncbi.nlm.nih.gov/pubmed/5968020 | https://www.researchgate.net/profile/James_Mcfarland6/publication/301747607_Metabolism_Considerations_During_the_Discovery_and_Development_of_Chlorpropamide_Pyrantel_Tetramisol_and_Certain_Alpha-adrenergic_Agonists/links/5754635608ae6807fb04ce0b.pdf

Antienite is a highly potent anthelmintic against nematodes in chickens and sheep. Antienite was also active in rodents but it was expensive and had limited solubility in water. These results led the Janssen pharmaceutical company to develop a close analog tetramisole.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:15:27 GMT 2023` Edited by `admin` on `Sat Dec 16 16:15:27 GMT 2023`
Record UNII	50Z1JVP72H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ANTIENITE

Official Name

English

R 8025

Code

English

R 8141

Code

English

(±)-5,6-DIHYDRO-6-(2-THIENYL)IMIDAZO(2,1-B)THIAZOLE

Systematic Name

English

R-8141

Code

English

antienite [INN]

Common Name

English

R-8025

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C250