Pyridarone is a 2-Pyridylbenzofuran derivative patented by Societe Belge de l'Azote et des Produits Chimiques du Marly S.A. as anxiolytic useful for the treatment of fear in emotions of psychogenic origin.

Droxicainide is a new antiarrhythmic agent. When given intravenously droxicainide suppressed ouabain-induced arrhythmias in pentobarbital-anesthetized guinea pigs. The initial experimental studies reported that droxicainide appears to have a more potent antiarrhythmic activity and fewer side effects than lidocaine. In local anesthetic tests and following intradermal administration to rabbits, droxicainide produced less local tissue irritation than lidocaine. Droxicainide is a class 1 anti-arrhythmic drug.

Olmidine (also known as dl-mandelamidine) is an antihypertensive drug that has never been marketed. Information about the current use of this drug is not available.

Brefonalol also known as BDF 8186, a beta-adrenergic blocking agent with vasodilating properties. This drug was being developed for the treatment of hypertension, arrhythmias and angina pectoris. However, these studies were discontinued.

Pentisomide is an agent structurally related to disopyramide. Pentisomide is a class-I antiarrhythmic agent with a marked effect on depolarization (action of class Ia and Ic) and on repolarization. Pentisomide dose-dependently inhibited ischaemia-reperfusion arrhythmia. Pentisomide had been in phase II clinical trial for the treatment of arrhythmias. The electrophysiologic effects of pentisomide were investigated after intravenous and oral application in patients with drug refractory atrioventricular nodal tachycardia and patients with orthodromic atrioventricular re-entrant tachycardia. If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either. Long-term treatment with pentisomide had to be discontinued because of possible side effects.

Adekalant (H 345/52) is a new antiarrhythmic compound with low proarrhythmic activity. H 345/52 concentration-dependently blocked HERG-carried currents with an IC50 of 230 nM. H 345/52 preferentially bound to the open channel with unusually rapid kinetics and was trapped by channel closure. Voltage-independent behavior of H 345/52 was observed during both square-pulse and action potential clamp protocols. It is proposed that block of IKr is the principal mechanism by which H 345/52 delays repolarization in human myocardium. H 345/52 blocks I(Kr) with high potency and I(Ca) with somewhat lower potency and was found to delay ventricular repolarisation without substantially increasing temporal or spatial dispersion and without inducing early after-depolarisations or TdP.

Nesapidil is a vasodilator, it is used as an antiarrythmic and antihypertensive therapy.

Pimefylline is an N-methylated xanthine derivative. It is a coronary vasodilator and muscle relaxant.

Cinepaxadil is cinnamoyl-piperazine derivative developed by Delalande SA for treatment cardiovascular system disorders. Cinepaxadil decrease dogs cardiac activity after i.v. administration.