DROXICAINIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H24N2O2
Molecular Weight	276.374
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC(C)=C1NC(=O)C2CCCCN2CCO

InChI

InChIKey=NVASAXNGHUPVJX-UHFFFAOYSA-N

InChI=1S/C16H24N2O2/c1-12-6-5-7-13(2)15(12)17-16(20)14-8-3-4-9-18(14)10-11-19/h5-7,14,19H,3-4,8-11H2,1-2H3,(H,17,20)

HIDE SMILES / InChI

Molecular Formula	C16H24N2O2
Molecular Weight	276.374
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6507117 | https://www.ncbi.nlm.nih.gov/pubmed/6683549 | https://www.ncbi.nlm.nih.gov/pubmed/6853899

Droxicainide is a new antiarrhythmic agent. When given intravenously droxicainide suppressed ouabain-induced arrhythmias in pentobarbital-anesthetized guinea pigs. The initial experimental studies reported that droxicainide appears to have a more potent antiarrhythmic activity and fewer side effects than lidocaine. In local anesthetic tests and following intradermal administration to rabbits, droxicainide produced less local tissue irritation than lidocaine. Droxicainide is a class 1 anti-arrhythmic drug.

Approval Year

PubMed

Title	Date	PubMed
Pharmacological studies on droxicainide, a new antiarrhythmic agent.	1983	6683549
Effects of lidocaine and droxicainide on myocardial necrosis: a comparative study.	1983 Jun	6853899
The acute antiarrhythmic effects of droxicainide and lidocaine in unanesthetized dogs.	1984 Mar-Apr	6200728
Comparison of electrophysiological and mechanical effects of droxicainide and lidocaine on heart muscle isolated from rats.	1984 Oct	6507117

Sample Use Guides

In Vivo Use Guide

2.5 mg/kg as a bolus and then as a continuous infusion for 6 hours (1.4 mg/kg).

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:27:22 GMT 2023` Edited by `admin` on `Fri Dec 15 16:27:22 GMT 2023`
Record UNII	J6W196LMV3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DROXICAINIDE

Official Name

English

ALS-1249

Code

English

2-PIPERIDINECARBOXAMIDE, N-(2,6-DIMETHYLPHENYL)-1-(2-HYDROXYETHYL)-

Systematic Name

English

droxicainide [INN]

Common Name

English

(±)-1-(2-HYDROXYETHYL)-2',6'-PIPECOLOXYLIDIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793