PENTISOMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H33N3O
Molecular Weight	319.4848
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CC(CCN(C(C)C)C(C)C)(C(N)=O)C1=CC=CC=N1

InChI

InChIKey=ZZOZYGHXNQPIPS-UHFFFAOYSA-N

InChI=1S/C19H33N3O/c1-14(2)13-19(18(20)23,17-9-7-8-11-21-17)10-12-22(15(3)4)16(5)6/h7-9,11,14-16H,10,12-13H2,1-6H3,(H2,20,23)

HIDE SMILES / InChI

Molecular Formula	C19H33N3O
Molecular Weight	319.4848
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1428255 | https://www.ncbi.nlm.nih.gov/pubmed/1725897 | https://www.ncbi.nlm.nih.gov/pubmed/8529527 | https://adisinsight.springer.com/drugs/800000271

Pentisomide is an agent structurally related to disopyramide. Pentisomide is a class-I antiarrhythmic agent with a marked effect on depolarization (action of class Ia and Ic) and on repolarization. Pentisomide dose-dependently inhibited ischaemia-reperfusion arrhythmia. Pentisomide had been in phase II clinical trial for the treatment of arrhythmias. The electrophysiologic effects of pentisomide were investigated after intravenous and oral application in patients with drug refractory atrioventricular nodal tachycardia and patients with orthodromic atrioventricular re-entrant tachycardia. If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either. Long-term treatment with pentisomide had to be discontinued because of possible side effects.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts.	1989 Jul	2738264
[Effects of oral pentisomide on ECG and hemodynamics].	1990 Dec	2093559
Effect of pentisomide (CM 7857) on myocardial excitation, conduction, repolarization, and refractoriness. An electrophysiological study in humans.	1991 Dec	1725897
Effects of pentisomide and E-4031 on canine atrial flutter due to reentry: a comparative study with disopyramide and propafenone.	1991 Jul	1719282
Evaluation of pentisomide on stable ventricular premature beats. Comparison with placebo.	1991 Jun	1713557
[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors].	1991 Sep	1959843
Binding profiles of class I antiarrhythmic agents to cardiac muscarinic receptors: competitive and allosteric interactions with the receptors and their pharmacological significance.	1991 Sep	1890628
Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia.	1992 Jul	1428255
Antiarrhythmic effect related to the plasma concentration of pentisomide in vivo and the antiarrhythmic-concentration relationship in vitro.	1995	8529527

Sample Use Guides

In Vivo Use Guide

900-1200 mg three times a day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:25:20 GMT 2023` Edited by `admin` on `Fri Dec 15 16:25:20 GMT 2023`
Record UNII	506T8KTW5Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PENTISOMIDE

Official Name

English

(±)-.ALPHA.-(2-(DIISOPROPYLAMINO)ETHYL)-.ALPHA.-ISOBUTYL-2-PYRIDINEACETAMIDE

Systematic Name

English

2-PYRIDINEACETAMIDE, .ALPHA.-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL)-.ALPHA.-(2-METHYLPROPYL)-

Systematic Name

English

PROPISOMIDE

Common Name

English

ME-3202

Code

English

PENTICAINIDE

Common Name

English

pentisomide [INN]

Common Name

English

PENTISOMIDE [MI]

Common Name

English

PENTISOMIDE [MART.]

Common Name

English

CM-7857

Code

English

PENTISOMIDE [JAN]

Common Name

English

Pentisomide [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793