U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 145351 - 145360 of 167129 results

Status:
Investigational
Source:
INN:tametraline [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Tametraline (also known as CP-24,441) is a norepinephrine-dopamine reuptake inhibitor that was developed as an Antidepressant agent. Information about the current use of this drug is not available.
Status:
Investigational
Source:
INN:bioresmethrin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Bioresmethrin is a synthetic pyrethroid insecticide. It is the (+)-trans isomer of resmethrin which itself contains a minimum of 30% bioresmethrin. Bioresmethrin is the [1R, trans] isomer of resmethrin and has greater insecticidal activity than the racemic mixture. Bioresmethrin is a potent contact insecticide effective against a wide range of household insects, plant pests, grain pests and insects found in animal housing. It exhibits a high order of insecticidal activity, which when coupled with its excellent toxicological properties, makes it potentially one of the safest and most useful insecticides now being produced.
Status:
Investigational
Source:
NCT02711553: Phase 2 Interventional Active, not recruiting Biliary Tract Cancer
(2016)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Merestinib (LY2801653) is a small molecule that has been shown in vitro to be a reversible type II ATP-competitive slowoff inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min−1 and a half-life (t1/2) of 525 min. Preclinical testing also has shown merestinib to inhibit several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, NTRK1/2/3, and DDR1/2 and the serine/threonine kinases MKNK1/2. Merestinib is being investigated in a phase II clinical trials in patients with biliary tract cancer, non-small cell lung cancer and solid tumours.
Status:
Investigational
Source:
INN:pentamethonium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Pentamethonium is a ganglionic blocking agent that was studied for the treatment of hypertension. In addition, this drug was used as an adjuvant to atropine in the therapy of paraoxon poisoning. Besides, it was used in surgical disease. However, information about the current application of this drug is not available.
Status:
Investigational
Source:
INN:melarsonyl potassium [INN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Melarsonyl is an arsenical anthelmintic compound. It has been used for the treatment of human trypanosomiasis and onchocerciasis.
Status:
Investigational
Source:
INN:prodeconium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Prodeconium Bromide is a Decamethylene derivative with neuromuscular blocking activity. Prodeconium Bromide acts as a muscle relaxant of short action and belongs to the group of mixed blocking agents. Its complete effect in man is obtained in 100 sec. and lasts for 7 min. Respiratory paralysis is produced by 1 mg/kg of Prodeconium
Status:
Investigational
Source:
INN:racefemine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Dextrofemine is the (+)-form of racefemine. It is antispasmodic agent. Dextrofemine was used as utrine spasmolytic or muscle relaxant.
Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms. Once ingested, psilocybin is rapidly metabolized to the psilocin, which then acts on serotonin receptors in the brain. Psilocybin was identified as the active hallucinogenic compound in magic mushrooms in 1959, but humans have used assorted psilocybin mushrooms in religious ceremonies since prehistoric times. In the 1960's psilocybin was marketed for use as a treatment for various psychoses, however, it was withdrawn from the market when the regulatory environment changed. Recently there has been as renewed interest in studying the medicinal uses of psilocybin for treatment of anxiety, depression, migraine headaches, addictions, and other neuropsychiatric conditions.
Status:
Investigational
Source:
INN:fenirofibrate
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

FENIROFIBRATE, (-)- is a metabolite of fenofibrate, an antilipemic agent which reduces both cholesterol and triglycerides in the blood.
Status:
Investigational
Source:
INN:picolamine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Picolylamine (PA), a derivatizing agent displaying a highly ESI-active pyridyl group that reacts with carboxylic acids in the presence of a condensation agent to form an amide derivative. Picolylamine is used as a derivatization reagent for the detection of endogenous carboxylic acids.

Showing 145351 - 145360 of 167129 results