MELARSONYL POTASSIUM

Details

Stereochemistry	MIXED
Molecular Formula	C13H11AsN6O4S2.2K
Molecular Weight	532.512
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].[K+].NC1=NC(NC2=CC=C(C=C2)[As]3SC(C(S3)C([O-])=O)C([O-])=O)=NC(N)=N1

InChI

InChIKey=PHCMFHVCRUCADN-UHFFFAOYSA-L

InChI=1S/C13H13AsN6O4S2.2K/c15-11-18-12(16)20-13(19-11)17-6-3-1-5(2-4-6)14-25-7(9(21)22)8(26-14)10(23)24;;/h1-4,7-8H,(H,21,22)(H,23,24)(H5,15,16,17,18,19,20);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	C13H11AsN6O4S2
Molecular Weight	454.316
Charge	-2
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10604048 | https://www.ncbi.nlm.nih.gov/pubmed/5309509 | https://www.cabdirect.org/cabdirect/abstract/19672902124

Melarsonyl is an arsenical anthelmintic compound. It has been used for the treatment of human trypanosomiasis and onchocerciasis.

Approval Year

PubMed

Title	Date	PubMed
[POTASSIUM MELARSONYL IN THE TREATMENT OF HUMAN ONCHOCERCIASIS. PRELIMINARY NOTE. FINDINGS AFTER 10 MONTHS OF OBSERVATION].	1964 May-Jul	14250534
The effects of drugs on Onchocerca volvulus. 4. Trials of melarsonyl potassium.	1970	5309509
Synthesis and in vitro anthelmintic properties of some new dithiaarsanes.	1999 Nov	10604048

Sample Use Guides

In Vivo Use Guide

The effects of the arsenical drug melarsonyl potassium on Onchocerca volvulus were investigated in patients in Cameroon infected with the Cameroon forest and Sudan savanna strains of the parasite. Two intramuscular dosage schedules were tested: the first comprised 4 consecutive daily doses of 200 mg repeated once after a 10-14 day interval, i.e., 2 (4x200 mg). The second was a single dose schedule at 7.1 mg/kg-10 mg/kg, with a maximum of 500 mg.

Route of Administration: Intramuscular

In Vitro Use Guide

On the M. dessetae model after a 24 h incubation period potassium melarsonyl exhibited an EC50 of 45.6 uM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:55:14 GMT 2023` Edited by `admin` on `Sat Dec 16 16:55:14 GMT 2023`
Record UNII	1484SU81EQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MELARSONYL POTASSIUM

Official Name

English

POTASSIUM PENTYL THIARSAPHENYLMELAMINE

Common Name

English

melarsonyl potassium [INN]

Common Name

English

POTASSIUM 2-(P-((4,6-DIAMINO-S-TRIAZIN-2-YL)AMINO)PHENYL)-1,3,2-DITHIARSOLANE-4,5-DICARBOXYLATE

Common Name

English

RP-9955

Code

English

MEL W

Brand Name

English

POTASSIUM MELARSONYL

Common Name

English

RP 9955

Code

English

Code System Code Type Description

EVMPD

SUB08720MIG