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Details

Stereochemistry MIXED
Molecular Formula C13H11AsN6O4S2.2K
Molecular Weight 532.512
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MELARSONYL POTASSIUM

SMILES

[K+].[K+].NC1=NC(NC2=CC=C(C=C2)[As]3SC(C(S3)C([O-])=O)C([O-])=O)=NC(N)=N1

InChI

InChIKey=PHCMFHVCRUCADN-UHFFFAOYSA-L
InChI=1S/C13H13AsN6O4S2.2K/c15-11-18-12(16)20-13(19-11)17-6-3-1-5(2-4-6)14-25-7(9(21)22)8(26-14)10(23)24;;/h1-4,7-8H,(H,21,22)(H,23,24)(H5,15,16,17,18,19,20);;/q;2*+1/p-2

HIDE SMILES / InChI
Melarsonyl is an arsenical anthelmintic compound. It has been used for the treatment of human trypanosomiasis and onchocerciasis.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

The effects of the arsenical drug melarsonyl potassium on Onchocerca volvulus were investigated in patients in Cameroon infected with the Cameroon forest and Sudan savanna strains of the parasite. Two intramuscular dosage schedules were tested: the first comprised 4 consecutive daily doses of 200 mg repeated once after a 10-14 day interval, i.e., 2 (4x200 mg). The second was a single dose schedule at 7.1 mg/kg-10 mg/kg, with a maximum of 500 mg.
Route of Administration: Intramuscular
On the M. dessetae model after a 24 h incubation period potassium melarsonyl exhibited an EC50 of 45.6 uM.
Name Type Language
MELARSONYL POTASSIUM
INN  
INN  
Official Name English
POTASSIUM PENTYL THIARSAPHENYLMELAMINE
Common Name English
melarsonyl potassium [INN]
Common Name English
POTASSIUM 2-(P-((4,6-DIAMINO-S-TRIAZIN-2-YL)AMINO)PHENYL)-1,3,2-DITHIARSOLANE-4,5-DICARBOXYLATE
Common Name English
RP-9955
Code English
MEL W
Brand Name English
POTASSIUM MELARSONYL
Common Name English
RP 9955
Code English
Code System Code Type Description
EVMPD
SUB08720MIG
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
NCI_THESAURUS
C166459
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
SMS_ID
100000081465
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
ECHA (EC/EINECS)
236-405-6
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
FDA UNII
1484SU81EQ
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
EPA CompTox
DTXSID70928181
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
INN
1256
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
CAS
16173-18-5
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
NON-SPECIFIC STOICHIOMETRY
CAS
13355-00-5
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY
PUBCHEM
25907
Created by admin on Sat Dec 16 16:55:14 GMT 2023 , Edited by admin on Sat Dec 16 16:55:14 GMT 2023
PRIMARY