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Restrict the search for
icosapent ethyl
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Class (Stereo):
CHEMICAL (ABSOLUTE)
Ersentilide (CK-3579 or HE93) is a blocker of beta1-adrenergic receptors and potassium channels. It exerts class III antiarrhythmic activity. It prevents ventricular fibrillation in a canine model of lethal arrhythmias.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Erbulozole (R 55104) is a water soluble congener of the microtubule inhibitor tubulozole, which has proven to possess anti-invasive, antitumoral and radiosensitizing capacities. Erbulozole development for the treatment of cancer has been discontinued.
Class (Stereo):
CHEMICAL (RACEMIC)
Furofenac (also known as SAS 650), a drug that has antiplatelet-aggregation activity and anti-inflammatory activity combined with low ulcerogenic power. It was shown that the furofenac mechanism of action involved the modulation of the platelet cyclooxygenase pathway.
Status:
Investigational
Source:
NCT00147485: Phase 1 Interventional Terminated Neoplasms
(2004)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Agouron (Pfizer) was developing AG-24322 (AG-024322), a small-molecule cyclin-dependent kinase (CDK) inhibitor, for the treatment of cancer. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. AG-24322 is a potent ATP-competitive inhibitor of
CDK1, CDK2, and CDK4 with Ki values in the 2–3 nM
range and selectivity over other non-CDKs. This compound
has been shown to inhibit Rb phosphorylation in cells, elicit
cell-cycle arrest, and have antiproliferative activity in multiple human tumor cell lines (IC50 values from 30 to 200 nM). AG-24322 was reported to be undergoing phase I trials for cancer in the US, however the development was discontinued.
Status:
Investigational
Source:
INN:sopromidine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Sopromidine is a neuroprotective drug. Sopromidine is a potent and stereoselective isomer of the achiral H2-agonist impromidine. The chiral impromidine isomer sopromidine is of special interest as the (R)-configurated compound behaves as gpH2R agonist, whereas the (S)-configurated counterpart is devoid of agonist activity. Both Sopromidine and its S enantiomer acted as antagonists of histamine at H3-autoreceptors with similar potencies (Ki = 5.6 X 10(-8) M and 4.5 X 10(-8) M), whereas Sopromidine acted as an H2-receptor agonist and the S-enantiomer as an H2-receptor antagonist.
Class (Stereo):
CHEMICAL (ACHIRAL)
Lodiperon exhibited neuroleptic activity with very low liability to the extrapyramidal side effects. Its activity was greater than that of butropipazone and fluanisone, while of the same order of that of chlorpromazine; however, lodiperon showed a longer lasting activity and minor ability to produce catalepsy as compared with the reference drugs.
Class (Stereo):
CHEMICAL (ACHIRAL)
Elfazepam is a benzodiazepine and a feed intake stimulant. Administration of elfazepam can induce animals to eat large meals. While rumen fermentation per se is not influenced by elfazepam, ruminal and abomasal motility and secretory functions are reduced.
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Elisartan (HN 65021) is a selective, orally active, nonpeptide angiotensin II (AT1) antagonist. It antagonizes angiotensin receptor-mediated vasoconstriction. Elisartan was being assessed for the treatment of hypertension.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Binfloxacin is a topoisomerase inhibitor that was studied as an antibacterial agent.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Fluoresone is an anticonvulsant, analgesic, anxiolytic agent. It is used in the treatment of epilepsy.
