ELISARTAN

Details

Stereochemistry	RACEMIC
Molecular Formula	C27H29ClN6O5
Molecular Weight	553.009
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC1=NC(Cl)=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=NN4)C(=O)OC(C)OC(=O)OCC

InChI

InChIKey=IDAWWPOAHPVPMY-UHFFFAOYSA-N

InChI=1S/C27H29ClN6O5/c1-4-6-11-22-29-24(28)23(26(35)38-17(3)39-27(36)37-5-2)34(22)16-18-12-14-19(15-13-18)20-9-7-8-10-21(20)25-30-32-33-31-25/h7-10,12-15,17H,4-6,11,16H2,1-3H3,(H,30,31,32,33)

HIDE SMILES / InChI

Molecular Formula	C27H29ClN6O5
Molecular Weight	553.009
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://adisinsight.springer.com/drugs/800002994 | https://www.ncbi.nlm.nih.gov/pubmed/8703667

Elisartan (HN 65021) is a selective, orally active, nonpeptide angiotensin II (AT1) antagonist. It antagonizes angiotensin receptor-mediated vasoconstriction. Elisartan was being assessed for the treatment of hypertension.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Type-1 angiotensin II receptor 40 Target ID: P30556 Gene ID: 185.0 Gene Symbol: AGTR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8703667	Antagonist 2778

PubMed

Title	Date	PubMed
The effect of HN-65021 on responses to angiotensin II in human forearm vasculature.	1995 Dec	8703667

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:18 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:18 GMT 2023`
Record UNII	WCC8Z95027
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ELISARTAN

Official Name

English

HN65021

Code

English

elisartan [INN]

Common Name

English

(±)-1-HYDROXYETHYL 2-BUTYL-4-CHLORO-1-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)IMIDAZOLE-5-CARBOXYLATE, ETHYL CARBONATE (ESTER)

Common Name

English

HN-65021

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C66930