LODIPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H20Cl2FN3O2
Molecular Weight	436.307
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C2=C(CCN3CCN(CC3)C4=CC(Cl)=CC(Cl)=C4)OC(=O)N2

InChI

InChIKey=VIASEBSYVIYYEZ-UHFFFAOYSA-N

InChI=1S/C21H20Cl2FN3O2/c22-15-11-16(23)13-18(12-15)27-9-7-26(8-10-27)6-5-19-20(25-21(28)29-19)14-1-3-17(24)4-2-14/h1-4,11-13H,5-10H2,(H,25,28)

HIDE SMILES / InChI

Molecular Formula	C21H20Cl2FN3O2
Molecular Weight	436.307
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2571727

Lodiperon exhibited neuroleptic activity with very low liability to the extrapyramidal side effects. Its activity was greater than that of butropipazone and fluanisone, while of the same order of that of chlorpromazine; however, lodiperon showed a longer lasting activity and minor ability to produce catalepsy as compared with the reference drugs.

Originator

Approval Year

PubMed

Title	Date	PubMed
5-Piperazinylalkyl-2(3H)-oxazolones with neuroleptic activity.	1989-10	2571727

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:10 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:10 GMT 2025`
Record UNII	T8593BT7B4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LODIPERONE

Official Name

English

5-(2-(4-(3,5-DICHLOROPHENYL)-1-PIPERAZINYL)ETHYL)-4-(P-FLUOROPHENYL)-4-OXAZOLIN-2-ONE

Preferred Name

English

lodiperone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197