FUROFENAC

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H14O3
Molecular Weight	206.2378
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1CC2=CC(CC(O)=O)=CC=C2O1

InChI

InChIKey=MYQXHLQMZLTSDB-UHFFFAOYSA-N

InChI=1S/C12H14O3/c1-2-10-7-9-5-8(6-12(13)14)3-4-11(9)15-10/h3-5,10H,2,6-7H2,1H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C12H14O3
Molecular Weight	206.2378
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7359316 | https://www.ncbi.nlm.nih.gov/pubmed/6475669

Furofenac (also known as SAS 650), a drug that has antiplatelet-aggregation activity and anti-inflammatory activity combined with low ulcerogenic power. It was shown that the furofenac mechanism of action involved the modulation of the platelet cyclooxygenase pathway.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cyclooxygenase pathway 5 Target ID: GO:0019371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6475669	Modulator 846
platelet aggregation 80 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7359316	Inhibitor 8504

PubMed

Title	Date	PubMed
Effect of SAS 650 (Furofenac) on malondialydehyde production by platelets.	1984-06	6475669
Mass spectrometry of the metabolites of 2-ethyl-2,3-dihydro-5-benzofuranylacetic acid.	1980-06	7426686
Metabolites and analogs of 2-ethyl-2,3-dihydro-5-benzofuranacetic acid (furofenac): chemical and pharmacological properties.	1980-02	7359316

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:02:35 GMT 2025` Edited by `admin` on `Mon Mar 31 18:02:35 GMT 2025`
Record UNII	86TB3JLD8A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SAS-650

Preferred Name

English

FUROFENAC

Official Name

English

5-BENZOFURANACETIC ACID, 2-ETHYL-2,3-DIHYDRO-

Systematic Name

English

furofenac [INN]

Common Name

English

2-ETHYL-2,3-DIHYDRO-5-BENZOFURANACETIC ACID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257