FUROFENAC

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H14O3
Molecular Weight	206.2378
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1CC2=C(O1)C=CC(CC(O)=O)=C2

InChI

InChIKey=MYQXHLQMZLTSDB-UHFFFAOYSA-N

InChI=1S/C12H14O3/c1-2-10-7-9-5-8(6-12(13)14)3-4-11(9)15-10/h3-5,10H,2,6-7H2,1H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C12H14O3
Molecular Weight	206.2378
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7359316 | https://www.ncbi.nlm.nih.gov/pubmed/6475669

Furofenac (also known as SAS 650), a drug that has antiplatelet-aggregation activity and anti-inflammatory activity combined with low ulcerogenic power. It was shown that the furofenac mechanism of action involved the modulation of the platelet cyclooxygenase pathway.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cyclooxygenase pathway 5 Target ID: GO:0019371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6475669	Modulator 828
platelet aggregation 76 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7359316	Inhibitor 8297

PubMed

Title	Date	PubMed
Metabolites and analogs of 2-ethyl-2,3-dihydro-5-benzofuranacetic acid (furofenac): chemical and pharmacological properties.	1980 Feb	7359316
Mass spectrometry of the metabolites of 2-ethyl-2,3-dihydro-5-benzofuranylacetic acid.	1980 Jun	7426686

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:36:05 GMT 2023` Edited by `admin` on `Fri Dec 15 15:36:05 GMT 2023`
Record UNII	86TB3JLD8A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FUROFENAC

Official Name

English

5-BENZOFURANACETIC ACID, 2-ETHYL-2,3-DIHYDRO-

Systematic Name

English

furofenac [INN]

Common Name

English

SAS-650

Code

English

2-ETHYL-2,3-DIHYDRO-5-BENZOFURANACETIC ACID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257