Inxight Drugs

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Development Status

US Approved OTC

10

Other

2

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Primary Target

Adrenergic receptor alpha-1

10

Adrenergic receptor alpha-2

10

Beta-1 adrenergic receptor

10

Beta-2 adrenergic receptor

10

Glycine receptor (alpha-1/beta)

2

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Highest Phase

Approved

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Approval Year

1928

10

Unknown

2

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Condition

Anesthesia-induced hypotension

10

Aplastic anemia

2

Glioma

2

Multiple myeloma

2

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Treatment Modality

Primary

12

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CNS Activity

CNS Active

12

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Originator

Nagai, N.

10

Pelletier, J.|Caventou, J.

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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EVMPD

8

SMS_ID

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

1

CARDIOVASCULAR SYSTEM

1

RESPIRATORY SYSTEM

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SENSORY ORGANS

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ATC Level 2

ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS

1

CARDIAC THERAPY

1

DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

1

NASAL PREPARATIONS

1

OPHTHALMOLOGICALS

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ATC Level 3

ADRENERGICS FOR SYSTEMIC USE

1

ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS

1

CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES

1

DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE

1

MYDRIATICS AND CYCLOPLEGICS

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ATC Level 4

Adrenergic and dopaminergic agents

1

Alpha- and beta-adrenoreceptor agonists

1

Centrally acting antiobesity products

1

Sympathomimetics excl. antiglaucoma preparations

1

Sympathomimetics, combinations excl. corticosteroids

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Substance Form

Salts, Hydrates, Esters, etc.

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Principal Form

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Showing 1 - 10 of 12 results

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Ephedrine

GN83C131XS

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

BRUCINE

6NG17YCK6H

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

T cell proliferation

Vascular endothelial growth factor receptor 2

Glycine receptor (alpha-1/beta)

Glycine receptor subunit alpha-1

Conditions:

Aplastic anemia

Multiple myeloma

Brucine is an alkaloid resembling strychnine but it is much less potent than strychnine. Brucine was first discovered in 1819 by Pelletier and Caventou in the bark of the Strychnos nux vomica tree. Brucine causes paralysis of the peripheral nerve end...

ings and produces violent convulsions. Since brucine is a large chiral molecule, it has been used as an enantioselective recognition agent using in chiral resolution. While brucine has been shown to have good anti-tumor effects, on both hepatocellular carcinoma and breast cancer, its narrow therapeutic window has limited its use as a treatment for cancer. Brucine is also used in traditional Chinese medicine as an anti-inflammatory and analgesic agent, as well as in some Ayurveda and homeopathy drugs. Like strychnine, brucine also functions as antagonist at the glycine receptor and paralyzes the inhibitory neurons

EPHEDRINE THIOCYANATE

TB6LCS628F

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

EPHEDRINE TARTRATE

WT9D3J0JEU

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

EPHEDRINE LEVULINATE

T9S008S8JL

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

EPHEDRINE ACEFYLLINATE

69LH6U1N27

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

EPHEDRINE HEMIHYDRATE

HH60WD6JQS

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

Ephedrine hydrochloride

NLJ6390P1Z

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

EPHEDRINE SULFATE

U6X61U5ZEG

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

Ephedrine (+)-camphorate

W56S9O8P5Y

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Status:

US Approved OTC

First marketed in 1928

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Adrenergic receptor alpha-1

Adrenergic receptor alpha-2

Conditions:

Anesthesia-induced hypotension

Ephedrine (l-form) is an alkaloid, which was initially purified from Ephedra plant. The extract form Ephedra has been used in China for medicinal purposes for several thousand years. Ephedrine acts as an agonist at alpha- and beta-adrenergic receptor...

s and indirectly causes the release of norepinephrine from sympathetic neurons. The drug crosses the blood brain barrier and stimulates the central nervous system. Ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine. FDA has approved ephedrine only for the treatment of clinically important hypotension occurring in the setting of anesthesia.

Showing 1 - 10 of 12 results

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