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US Approved Rx

11

US Approved OTC

3

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Primary Target

Oxidative Stress

11

Thiamin pyrophosphokinase 1

11

carbohydrate metabolic process

11

hemopoiesis

3

platelet aggregation

3

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Highest Phase

Approved

14

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Approval Year

1947

11

1950

3

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Condition

Thiamine deficiency

11

Cancer

3

Fecal incontinence

3

Radiation-induced hematopoietic syndrome

3

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Treatment Modality

Preventing

11

Palliative

3

Primary

3

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CNS Activity

CNS Penetrant

14

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Originator

Eijkman, C.

11

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Chemical

13

Mixture

1

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CAS

14

FDA UNII

14

PUBCHEM

11

EPA CompTox

10

ECHA (EC/EINECS)

6

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

1

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ATC Level 2

VITAMINS

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ATC Level 3

VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12

1

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ATC Level 4

Vitamin B1, plain

1

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Substance Form

Salts, Hydrates, Esters, etc.

12

Principal Form

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Showing 1 - 10 of 14 results

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THIAMINE ION

4ABT0J945J

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

PHYTOCHLORIN

5S2CCF3T1Z

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Status:

US Approved OTC

First approved in 1950

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

platelet aggregation

Conditions:

Fecal incontinence

Radiation-induced hematopoietic syndrome

Chlorophyllin is a water soluble derivative of chlorophyll. It has chemopreventive properties and forms a non-covalent complex with many mutagenic/carcinogenic molecules. Chlorophyllin inhibits cancer initiation and progression by targeting multiple ...

molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis. The modulatory effects of Chlorophyllin to be mediated via abrogation of key oncogenic signal transduction pathways such as nuclear factor kappa B, Wnt/β-catenin, and phosphatidylinositol-3-kinase/Akt signaling. Chlorophyllin sodium copper salt mitigates radiation-induced hematopoietic syndrome by increasing the abundance of hematopoietic stem cells, enhancing granulopoiesis, and stimulating prosurvival pathways in bone marrow cells and lymphocytes. In addition, chlorophyllin exhibits antioxidant, antiapoptotic and immunostimulatory effects. Chlorophyllin is intended to improve the quality of life in people who have fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorder, terminal illness, or other disorders. Chlorophyllin is also used by people who have had a colostomy or ileostomy

THIAMINE CAMSILATE

AS1A8DF3EU

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE

X66NSO3N35

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE HYDROBROMIDE HEMIHYDRATE

WV7TS40872

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE HYDROBROMIDE ANHYDROUS

K971V37HSF

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE BIS-LAURYLSULFATE

226A8HU328

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE NAPHTHALENE-1,5-DISULFONATE

ZWY7D9M9UB

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE BROMIDE

JIJ7B8T57F

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE HYDROCHLORIDE

M572600E5P

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

Showing 1 - 10 of 14 results

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