U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 61 - 70 of 186 results

Status:
Investigational
Source:
INN:dietifen [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:

Dietifen is an anesthetic, vasodilator and antifungal agent. The main pharmacological feature of the drug is its ability to cause expansion of the coronary vessels. It also has a moderate spasmolytic activity (reduces spasms of the muscles of the intestine and other internal organs) and somewhat inhibits the conduction of nervous excitement through the vegetative nodes. Significant changes in blood pressure and pulse rate does not cause, does not possess hormonal (estrogenic) activity. It is indicated for the treatment of chronic coronary insufficiency, angina pectoris, severe forms of coronary sclerosis and pre-infarction conditions (simultaneously with anticoagulants).
Status:
Investigational
Source:
INN:bisorcic
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Bisorcic is an N-acetyl-L-amino acid that is L-ornithine was developed as a hepatoprotective agent and was studied as a psychostimulant.
Status:
Investigational
Source:
INN:declenperone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Declenperone is an antagonist of 5-HT2 receptors, developed by Janssen Pharmaceutica. The compound is claimed to have strong neuroleptic activity, as evidenced by experimental data obtained in apomorphine-tryptamine and norepinephrine test in rats, and the apomorphine test in dogs. Declenperone was used in a veterinary as a sedative.
Status:
Investigational
Source:
INN:dimetholizine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dimetholizine has antihypertensive activity. It is an antihistaminic agent too. Histamine H1 receptor was predicted as a primary target for dimetholizine. Moreover, it was found to bind the Dopamine D2 and 5-HT1A receptors. Dimetholizine was predicted to be alpha1D-Adrenergic blocker.
Status:
Investigational
Source:
INN:divabuterol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Divabuterol or terbutaline dipivalate is a prodrug of terbutaline. The half-life of terbutaline dipivalate in human plasma is less than five minutes. Therapeutically, most forms of terbutaline can be used as bronchodilators in antiasthmatic treatment, as smooth muscle relaxants to treat premature labour (uterine relaxant) and for a number of other indications.
Status:
Investigational
Source:
INN:ethypicone [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Ethypicone is a hypnotic and sedative agent.
Status:
Investigational
Source:
INN:prodeconium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Prodeconium Bromide is a Decamethylene derivative with neuromuscular blocking activity. Prodeconium Bromide acts as a muscle relaxant of short action and belongs to the group of mixed blocking agents. Its complete effect in man is obtained in 100 sec. and lasts for 7 min. Respiratory paralysis is produced by 1 mg/kg of Prodeconium
Status:
Investigational
Source:
INN:drazidox
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Drazidox is the antiseptic agent.
Status:
Investigational
Source:
INN:cipropride
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)


Cipropride is an anti-emetic drug of the substituted benzamide class. It was discovered by Synthelabo in the early 1980s. The drug acts by blocking the dopamine receptor and thus affecting the chemo-receptor trigger zone for vomiting. Clinical trials showed that cipropride was effective for the prevention of nausea and vomiting induced by cytotoxic chemotherapy agents dacarbazine and Cis-platinum. The subsequent development of the drug was not reported.
Status:
Investigational
Source:
INN:deditonium bromide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Deditonium is an antibacterial compound developed by the French company Centre de Recherches des Laboratoires Diamant. Deditonium is a quaternary ammonium derivative and has a bacteriostatic action at concentrations ranging from 1x10-6 to 5x10-4 M. Gram-positive cocci were found to be the most sensitive as well as many enterobacteria.