DECLENPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H24FN3O2
Molecular Weight	381.4433
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C(=O)C2CCN(CCCN3C(=O)NC4=CC=CC=C34)CC2

InChI

InChIKey=VNLMLHDKNUIWNM-UHFFFAOYSA-N

InChI=1S/C22H24FN3O2/c23-18-8-6-16(7-9-18)21(27)17-10-14-25(15-11-17)12-3-13-26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-9,17H,3,10-15H2,(H,24,28)

HIDE SMILES / InChI

Molecular Formula	C22H24FN3O2
Molecular Weight	381.4433
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://patents.google.com/patent/GB1532546 | https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430080116 | https://link.springer.com/book/10.1007/978-1-4757-2085-3#about

Declenperone is an antagonist of 5-HT2 receptors, developed by Janssen Pharmaceutica. The compound is claimed to have strong neuroleptic activity, as evidenced by experimental data obtained in apomorphine-tryptamine and norepinephrine test in rats, and the apomorphine test in dogs. Declenperone was used in a veterinary as a sedative.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2 (5-HT2) receptor 87 Target ID: CHEMBL2095200 Sources: https://link.springer.com/book/10.1007/978-1-4757-2085-3#about \| https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.430080116	Antagonist 2778

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:22:19 GMT 2023` Edited by `admin` on `Fri Dec 15 16:22:19 GMT 2023`
Record UNII	280VGV0X4H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DECLENPERONE

Official Name

English

2H-BENZIMIDAZOL-2-ONE, 1-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPYL)-1,3-DIHYDRO-

Systematic Name

English

DECLENPERONE [USAN]

Common Name

English

declenperone [INN]

Common Name

English

NSC-328505

Code

English

R 33,204

Code

English

1-(3-(4-(P-FLUOROBENZOYL)PIPERIDINO)PROPYL)-2-BENZIMIDAZOLINONE

Common Name

English

R-33204

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C28197