17-epidrospirenone is an epimer of drospirenone, considered to be impurity. Drospirenone is a synthetic progestational compound used as a component of oral contraceptive in combination with ethinyl estradiol.

17-epidrospirenone is a derivative of drospirenone with a reversed configuration of the 17-spirolactone ring had no biological activity. Drospirenone impurity. Drospirenone is a synthetic progestational compound used as a component of oral contraceptive in combination with ethinyl estradiol.

PSN375963 is agonist of GPR119 receptor. Treatment of mice islet cells with PSN375963 stimulated insuline resistance.

Articaine, a dental local anesthetic, is metabolized into articaine acid. The last is excreted as such or further transforms into the glucuronidated metabolite.

Omeprazole sulfone is the major metabolite of the omeprazole, gastric proton pump inhibitor. Metabolite is formed by the sulfoxidation of the omeprazole under the action of cytochrome P450 (CYP)3A4. Omeprazole sulfone is found in plasma and shows elimination rate–limited kinetics in vivo. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19.

3-Trifluoromethylisobutyranilide is one of Flutamide impurity.

PF 4800567 is a drug developed by Pfizer which acts as a selective potent inhibitor of CK1epsilon (IC(50) = 32 nM) with greater than 20-fold selectivity over CK1delta, and has mainly been used in the study of the casein kinase 1 enzymes in the regulation of circadian rhythm, as well as showing potential neuroprotective effects. PF 4800567 was found in animal studies to enhance responses to certain drugs of abuse such as methamphetamine and fentanyl, which suggests a role for CK1-ε in negative regulation of sensitivity to stimulant and opioid drugs.

Ro 67-4853 exhibited activity at all group I of metabotropic glutamate receptors including mGluR1 and mGluR5. It enhances the effects of (S)-DHPG in CA3 neurons. Site-directed mutagenesis revealed that valine at position 757 in transmembrane V of mGluR1 is crucial for the activity of multiple classes of allosteric mGluR1 potentiators. The discovery of selective mGluR1 enhancers opens the possibility for therapeutically relevant positive modulation of family 3 G proteincoupled receptors.

Methoxy-PEPy is a selective ligand for the Metabotropic Glutamate Subtype 5 (mGlu5) Receptor. [3H]Methoxy-PEPy is used as a radiolabel to study mGlu5 R distribution and binding with other agents.

4-(2-Keto-1-benzimidazolinyl)piperidine is building block for preparing potent anticancer compounds.