RO-67-4853

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H19NO4
Molecular Weight	325.3585
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCOC(=O)NC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13

InChI

InChIKey=RQBUXEUMZZQUFY-UHFFFAOYSA-N

InChI=1S/C19H19NO4/c1-2-3-12-23-19(22)20-18(21)17-13-8-4-6-10-15(13)24-16-11-7-5-9-14(16)17/h4-11,17H,2-3,12H2,1H3,(H,20,21,22)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11606768
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/16645124

Ro 67-4853 exhibited activity at all group I of metabotropic glutamate receptors including mGluR1 and mGluR5. It enhances the effects of (S)-DHPG in CA3 neurons. Site-directed mutagenesis revealed that valine at position 757 in transmembrane V of mGluR1 is crucial for the activity of multiple classes of allosteric mGluR1 potentiators. The discovery of selective mGluR1 enhancers opens the possibility for therapeutically relevant positive modulation of family 3 G proteincoupled receptors.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Metabotropic glutamate receptor 1 25 Target ID: CHEMBL3772 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11606768 \| https://www.ncbi.nlm.nih.gov/pubmed/16645124	Positive Allosteric Modulator 179		7.16 null [pEC50]
Metabotropic glutamate receptor 5 39 Target ID: CHEMBL2564 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11606768	Positive Allosteric Modulator 179

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.	2001 Nov 6	11606768
Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus.	2014 Apr	24373900
Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.	2014 Jan 17	24280223

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Concentration-response curves for the effect of Ro 67-4853 was generated in CA3 neurons by using 5 uM S-DHPG. The maximum potentiation of the S-DHPG effect by Ro 67-4853 was 637 % of control. Ro 67-4853 was potent in enhancing the effect of S-DHPG with EC50 values of 95 nM.

Name

Type

Language

RO-67-4853

Code

English

CARBAMIC ACID, (9H-XANTHEN-9-YLCARBONYL)-, BUTYL ESTER

Systematic Name

English

CARBAMIC ACID, N-(9H-XANTHEN-9-YLCARBONYL)-, BUTYL ESTER

Systematic Name

English

RO67-4853

Code

English

BUTYL N-(9H-XANTHEN-9-YLCARBONYL)CARBAMATE

Systematic Name

English

Code System Code Type Description

PUBCHEM

9949202