4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H15N3O
Molecular Weight	217.267
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE

Structure Search

SMILES

O=C1NC2=C(C=CC=C2)N1C3CCNCC3

InChI

InChIKey=BYNBAMHAURJNTR-UHFFFAOYSA-N

InChI=1S/C12H15N3O/c16-12-14-10-3-1-2-4-11(10)15(12)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,16)

HIDE SMILES / InChI

Molecular Formula	C12H15N3O
Molecular Weight	217.267
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25131537
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/28218826

4-(2-Keto-1-benzimidazolinyl)piperidine is building block for preparing potent anticancer compounds.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.	2006-04-15	16458510
SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists.	2005-08-01	15978807
Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.	2005-03-15	15745822
In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin.	2002-04	11910261
N-acylated alpha-(3-pyridylmethyl)-beta-aminotetralin antagoinists of the human neuropeptide Y Y5 receptor.	2000-08-07	10937714

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Compound (3, 4-(2-Keto-1-benzimidazolinyl)piperidine) activity was evaluated by annexin V/propidium iodide staining-based flow cytometric analysis in human K562 cells after 48h of treatment.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:02:59 GMT 2025` Edited by `admin` on `Mon Mar 31 22:02:59 GMT 2025`
Record UNII	4RP0AED2PC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

R-30507

Preferred Name

English

4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE

Systematic Name

English

4-(2-OXO-1,3-DIHYDROBENZIMIDAZOL-1-YL)PIPERIDINE

Systematic Name

English

4-(2-OXO-1-BENZIMIDAZOLINYL)PIPERIDINE

Systematic Name

English

1-(4-PIPERIDINYL)-2-BENZIMIDAZOLONE

Systematic Name

English

2H-BENZIMIDAZOL-2-ONE, 1,3-DIHYDRO-1-(4-PIPERIDINYL)-

Systematic Name

English

1-(PIPERIDIN-4-YL)-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE

Systematic Name

English

PIMOZIDE IMPURITY A [EP IMPURITY]

Common Name

English

4-(2-OXO-1-BENZIMIDAZOLY)PIPERIDINE

Systematic Name

English

4-(2-OXO-1,3-DIHYDRO-2H-BENZIMIDAZOL-1-YL)PIPERIDINE

Systematic Name

English

Code System Code Type Description

FDA UNII

4RP0AED2PC